冠状动脉周围脂肪衰减指数与高TyG人群发生冠状动脉粥样硬化风险的研究OA

Objective:To investigate the association between pericoronary fat attenuation index(FAI)and the risk of coro-nary artery atherosclerosis(CAS)in individuals with high triglyceride-glucose index(TyG),and to evaluate its predictive value.Methods:This retrospective study enrolled inpatients who underwent coronary computed tomography angiography(CCTA)in our hospital from January to December 2020 for chest tightness,chest pain,palpitations,or suspected coronary heart dis-ease,and were clinically diagnosed with dyslipidemia.A total of 235 subjects with TyG≥8.18 were included,comprising 169 CAS-positive and 66 CAS-negative cases.The FAI and volume of pericoronary adipose tissue(PCAT)surrounding the left anterior descending artery,left circumflex artery,and right coronary artery were measured.Independent predictors were iden-tified using binary Logistic regression,and receiver operating characteristic(ROC)curves and the area under the curve(AUC)were used to assess the discriminative performance of the models.Results:Multivariable analysis showed that age(OR=1.06),body mass index(BMI)(OR=1.127),LCX-FAI(OR=1.075 5),and LCX-PCAT volume(OR=1.001)were independent predictors of CAS.The AUC of LCX-FAI alone was 0.610(cutoff value,-74.5 HU),and the AUC increased to 0.700 when LCX-FAI was combined with age and BMI.Conclusion:Elevated PCAT-FAI is associated with CAS in individuals with a high TyG.LCX-FAI combined with age and BMI may improve risk identification.