18F-FAPI-04 PET/CT半定量参数在高风险乳腺结节良恶性鉴别中的临床应用研究OA

Objective:To investigate the diagnostic value of 18F-FAPI-04 PET/CT in differentiating benign and malignant high-risk breast nodules,as well as the diagnostic performance of its semi-quantitative parameters.Methods:A retrospective analysis was conducted on 53 patients who underwent 18F-FAPI-04 PET/CT at the Second Affiliated Hospital of Guangxi Medical University from January 2024 to August 2025,following ultrasound diagnoses of BI-RADS 4 and 5 breast lesions.A total of 67 breast nodules were detected,including 49 pathologically diagnosed as breast cancer and 18 as benign lesions.Fol-lowing 18F-FAPI-04 PET/CT scanning,the SUVmax and SUVmean of the breast lesions and background tissue were obtained by outlining the regions of interest(ROI),and the lesion-to-background ratio(LBR)was calculated.Mann-Whitney U tests were used to analyze the differences in semi-quantitative parameters between groups.ROC curves were plotted,and the sensitivity,specificity,AUC,and Youden index at the optimal thresholds for SUVmax and LBR were calculated to evaluate diagnostic per-formance.The Delong test was applied to compare AUC differences.Results:The SUVmax and LBR in the breast cancer group were significantly higher than those in the benign lesion group,with statistically significant differences(P＜0.001).The optimal thresholds for SUVmax and LBR were 4.51 and 4.39,respectively.At these thresholds,both parameters showed high diagnostic performance,with sensitivities of 98%and 87.8%,respectively,and 100%specificity for both.The AUC values for SUVmax and LBR were 0.99 and 0.97,respectively,and no significant difference was observed in diagnostic performance between the two(P=0.113).Conclusion:This study demonstrates that 18F-FAPI-04 PET/CT can effectively differentiate between benign and malignant high-risk breast lesions,with SUVmax exhibiting the highest diagnostic performance.