Ⅰ型脑小血管病伴认知障碍静息态功能磁共振成像研究OA

Objective:To investigate brain functional network characteristics in patients with type Ⅰ cerebral small ves-sel disease(CSVD)related vascular cognitive impairment(VCI)using resting-state functional MRI(fMRI).Methods:A patient(PT)group consisting of individuals who met the diagnostic criteria for type Ⅰ CSVD and a normal control(NC)group were enrolled.Grouping was determined based on the Montreal Cognitive Assessment(MoCA)and a summary CSVD score(sCSVD).Multimodal functional metrics(ALFF/fALFF/ReHo)and independent component analysis(ICA)were applied to assess inter-group differences.Correlation analyses were conducted between sCSVD,cognitive scores,and functional parameters.Results:The MoCA score exhibited a significantly negative correlation with sCSVD(r=-0.818,P＜0.001).A comparison between the PT group and the NC group revealed significant inter-group differences in the age,years of education,and prevalence of hypertension among the participants,with P＜0.05.Differential brain regions were identified for ALFF,fALFF,and ReHo,with P＜0.001(uncorrected).The effect sizes of these differences showed weak correlations with demographic data,sCSVD,and the MoCA score(|r|0.2～＜0.5,P＜0.05).Independent component analysis demonstrated abnormal inter-network connectiv-ity,with P＜0.05(uncorrected).Conclusion:Type Ⅰ CSVD severity is significantly associated with VCI,with cognitive deficits worsening as pathological burden increases effect.Advanced age and hypertension accelerate disease progression,whereas a higher educational level exerts a protective effect.Compensatory reorganization and functional imbalance coexist in whole-brain network reconfiguration,despite weak spatial correlations between localized functional changes and cognitive impair-ment.