依达拉奉右莰醇治疗对急性脑梗死患者血清ANXA2、miR-141-3p与脑损伤标志物影响的临床研究OA

Objective This study examines the therapeutic effects of edaravone and borneol in patients with acute cerebral infarction,as well as their impact on serum annexin A2(Annexin Ⅱ,ANXA2),microRNA-141-3p(miR-141-3p),and markers of brain injury,and conducts an in-depth analysis of their correlations.Method A total of 150 patients with acute cerebral infarction admitted to the Department of Neurology at our hospital between January 2024 and March 2025 were selected as study subjects.They were randomly assigned to either the control group(75 patients:standard treatment)or the experimental group(75 patients:standard treatment plus edaravone and dextro-camphor)based on their treatment regimens.The primary outcome measures[ANXA2,miR-141-3p,markers of brain injury,and National Institutes of Health Stroke Scale(NIHSS)scores],as well as secondary outcome measures[Mini-Mental State Examination(MMSE)scores,oxidative stress markers,Montreal Cognitive Assessment(MoCA)scores,haemorheological parameters,Chinese Stroke Scale(CSS)scores,cerebral haemodynamic parameters,and clinical efficacy].Pearson's correlation analysis was used to examine the relationship between ANXA2 and miR-141-3p levels and markers of brain injury.Results At 14 days of treatment,the levels of ANXA2 in the experimental and control groups were(27.49±6.87)and(23.54±5.88)ng·mL-1,respectively;those of miR-141-3p were(0.86±0.22)and(1.24±0.31),respectively;intercellular adhesion molecule-1(ICAM-1)were(177.35±41.84)and(204.16±51.04)μg·L-1,homocysteine(Hcy)were(20.84±4.96)and(23.78±5.95)μmol·L-1,endothelin-1(ET-1)were(109.42±27.36)and(125.33±31.33)ng·L-1,neuron-specific enolase(NSE)were(27.84±6.46)and(31.52±7.88)μg·L-1,glial fibrillary acidic protein(GFAP)were(8.63±1.81)and(9.54±2.38)μg·L-1,respectively;S100 calcium-binding protein B(S100B)were(30.35±7.34)and(34.76±8.69)ng·L-1,respectively;and the NIHSS scores were(9.06±2.27)and(13.61±3.42)points,respectively.Compared with the control group,the differences in the aforementioned indicators in the experimental group were statistically significant(P＜0.05).After treatment,the overall response rates in the study group and the control group were 96.00％(72/75)and 80.00％(60/75),respectively;the difference was statistically significant(P＜0.05).The Pearson correlation analysis revealed that ANXA2 was negatively correlated with markers of brain injury,while miR-141-3p was positively correlated with these markers;these differences were statistically significant(P＜0.05).Conclusion Patients with acute cerebral infarction have shown favorable outcomes following treatment with edaravone and borneol camphor;this therapy improves the levels of markers such as miR-141-3p and ANXA2,enhances cognitive function,and promotes recovery from the disease.Furthermore,both ANXA2 and miR-141-3p are closely associated with markers of brain injury.