双环醇对妇科肿瘤化疗所致肝功能指标异常的短期评估OA

AIM:To explore the effect of bicyclol in preventing and treating abnormal liver function indexs,which induced by chemotherapy in gyneco-logic tumors.METHODS:A total of 40 patients with abnormal liver function indices induced by chemotherapy for gynecologic tumors were select-ed from 2020 to 2022.They were divided into the bicyclol treatment group and the glycyrrhizin treat-ment(oral diammonium glycyrrhizinate enteric-coated capsules or compound glycyrrhizin tablets).Compared the changes in liver function indexs to evaluate the effect and adverse reaction between the two groups.RESULTS:After chemotherapy,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl trans-ferase(GGT),alkaline phosphatase(ALP),total bilirubin(TBIL),and direct bilirubin(DBIL)elevated.Following hepatoprotective treatment,these in-dexs decreased in both groups.Bicyclol tables re-duced ALT more significantly than glycyrrhizin group(P<0.05).There was not adverse reactions in either group.CONCLUSION:Oral glycyrrhizin and bicyclol tablets are both effective in alleviating abnormal liv-er function indices caused by chemotherapy in gy-necologic tumors.Compared to oral glycyrrhizin,bi-cyclol tablets demonstrate a superior effect in re-ducing liver enzyme levels.Patients with significant-ly elevated liver enzyme levels should consider bicy-clol tablets as the preferred treatment option.