中枢听觉测验联合脑电特征在阿尔茨海默病源性轻度认知障碍早期筛查中的应用OA
Application of central auditory testing combined with electroencephalogram characteristics in the early screening of mild cognitive impairment due to Alzheimer's disease
目的 探讨中枢听觉测验联合脑电特征在阿尔茨海默病源性轻度认知障碍早期筛查中的应用. 方法 采用便利抽样法,于2025年7月至9月在江苏省南京市栖霞区社区招募40例阿尔茨海默病源性轻度认知障碍老年人和23例认知正常老年人.采用听觉N-back和双耳分听经典范式进行测评,同步采集北京版蒙特利尔认知评估量表(MoCA-BJ)评分和32导联脑电数据.通过二元Logistic回归分析筛选预测指标,绘制受试者工作特征曲线并计算曲线下面积(AUC). 结果 双耳分听总分与MoCA-BJ总分呈正相关(r=0.475,P<0.01),右耳优势与整体认知、视空间、抽象能力和延迟回忆呈负相关(r<-0.276,P<0.05).N-back各条件下任务均与整体认知功能呈正相关(r>0.249,P<0.05).脑电特征方面,δ与θ波功率、功率峰值与延迟回忆呈正相关(r>0.258,P<0.05),(α+θ)/(α+β)及θ/(α+β)分别与命名能力和视空间执行呈正相关(r>0.261,P<0.05).双耳分听总分、1-back正确率、δ波平均功率和θ/(α+β)比值是阿尔茨海默病源性轻度认知障碍的独立影响因素(P<0.05).听觉任务表现和脑电特征的AUC分别为0.845和0.735,两者联合后AUC提升至0.862. 结论 基于听觉任务表现和脑电特征融合的筛查模型在阿尔茨海默病源性轻度认知障碍早期识别中具有较高的分类准确性.
Objective To investigate the application of central auditory testing combined with electroencephalographic features in the early screening of mild cognitive impairment due to Alzheimer's disease. Methods A convenience sampling method was used to conduct a field survey in the Qixia District of Nanjing City,Jiang-su Province,from July to September,2025.A total of 40 older adults diagnosed as mild cognitive impairment due to Alzheimer's disease and 23 cognitively normal older adults were recruited.Auditory N-back and dichotic lis-tening paradigms were employed for assessment,while the scores of Montreal Cognitive Assessment Beijing Ver-sion(MoCA-BJ)and 32-channel electroencephalogram(EEG)data were simultaneously collected.Binary logis-tic regression analysis was applied to identify predictive indicators,receiver operating characteristic(ROC)curves were plotted,and the area under the curve(AUC)was calculated. Results The total score of dichotic listening was positively correlated with overall cognitive function(r=0.475,P<0.01),while right-ear advantage showed negative correlations with overall cognition,visuospatial ability,abstract reasoning,and delayed recall(r<-0.276,P<0.05).Task performance across all conditions of the N-back task was positively correlated with overall cognitive function(r>0.249,P<0.05).Regarding EEG features,δ and θ band power and power peaks were positively correlated with delayed recall(r>0.258,P<0.05),whereas(α+θ)/(α+β)and θ/(α+β)were positively correlated with naming ability and visuospatial executive function,respective-ly(r>0.261,P<0.05).The results of the binary logistic regression analysis showed that the total score of binau-ral dichotic listening,the accuracy of 1-back task,the average power of δ waves,and the ratio of θ/(α+β)were in-dependent influencing factors for mild cognitive impairment due to Alzheimer's disease(P<0.05).The ROC analysis indicated that the AUC for auditory task performance and EEG features were 0.845 and 0.735 respective-ly,and when combined,the AUC increased to 0.862. Conclusion The screening model based on the integration of auditory task performance and EEG features can be used in the early identification of mild cognitive impairment due to Alzheimer's disease.
孙凤仪;殷海燕;尹婷婷;杨冰清;顾剑鹏;汪妍;柏亚妹;徐桂华;宋玉磊
南京中医药大学护理学院,江苏 南京市 210023南京中医药大学护理学院,江苏 南京市 210023南京中医药大学护理学院,江苏 南京市 210023南京中医药大学护理学院,江苏 南京市 210023南京中医药大学护理学院,江苏 南京市 210023南京中医药大学护理学院,江苏 南京市 210023南京中医药大学护理学院,江苏 南京市 210023南京中医药大学护理学院,江苏 南京市 210023南京中医药大学护理学院,江苏 南京市 210023
医药卫生
阿尔茨海默病源性轻度认知障碍中枢听觉测验脑电老年人早期筛查
mild cognitive impairment due to Alzheimer's diseasecentral auditory testelectroencephalogramolder adultsearly screening
《中国康复理论与实践》 2026 (9)
1016-1024,9
1.国家重点研发计划项目(No.2023YFC3603600)2.江苏高校优势学科四期项目南京中医药大学护理学科开放课题(No.YSHL202503)3.江苏省研究生实践创新计划课题(No.SJCX25_0908) Supported by National Key Research and Development Program of China(No.2023YFC3603600),the Open Projects of the Discipline of Nursing of Nanjing University of Chinese Medicine Supported by Superior Discipline Phase IV Project of Jiangsu Higher Education Institutions(No.YSHL202503),and Postgraduate Practice Innovation Program of Jiangsu Province(No.SJCX25_0908)
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