青少年特发性脊柱侧凸预期姿势调节凸凹侧不对称性的多模态神经机制研究OA

Objective:To investigate the central-peripheral-biomechanical features of anticipatory postural adjust-ments in adolescent idiopathic scoliosis(AIS)during a rapid arm raise task.Methods:Totally,38 subjects were en-rolled:11 healthy controls,14 mild AIS,and 13 moderate AIS.Participants performed rapid bilateral arm raises while 32-channel electroencephalography,surface electromyography of eight trunk muscles,and force platform cen-ter of pressure(COP)data were synchronously recorded.Single-trial EEG movement-related cortical potentials and event-related desynchronization were extracted using sEMG-detected movement onset as the temporal anchor and ag-gregated after group-level outlier cleaning.Statistical analysis combined trial-level linear mixed models with subject-level analysis of covariance in a hierarchical strategy.Results:The mild group showed lower convex-side paraspinal integrated EMG than the concave side,whereas the moderate group exhibited a reversed pattern with high-energy convex-side compensation(P=0.006).Movement-related cortical potential amplitude followed an health control>mild>moderate gradient(P=0.018).Body mass index independently modulated both central motor preparation timing and peripheral postural mechanical output(P=0.007).Thoracic-curve sensitivity analysis confirmed these findings.Conclusion:The primary APA abnormality in AIS is convex/concave paraspinal energy maldistribution that worsens during repeated rapid movements.BMI may modulate both cortical preparation timing and biomechani-cal postural output through inertial loading.Convex/concave mapping combined with synchronized EEG-sEMG-COP analysis may help characterize neuromuscular control deficits in AIS and may provide a basis for individualized fatigue-aware rehabilitation assessment.