早中期帕金森病患者全维度注意功能特征及注意功能亚型分类研究OA

Objective:To describe the characteristics of full-dimensional attention function changes in patients with early-to-mid stage Parkinson's disease(PD),explore classification based on attention function,and compare the differences in cognitive and motor functions among attention function subtypes.Methods:This was a cross-sectional study.A total of 112 patients with early-to-mid stage primary PD and 30 normal controls matched for sex,age,and years of education were enrolled.The digit span test,trail making test,stroop color-word test,and paced auditory serial addition test(PASAT)were used to assess each attention dimension.The mini-mental state examination and montreal cognitive assessment were used for global cognitive function,and the movement disorder society unified Parkinson's disease rating scale part Ⅲ was used to evaluate motor function.We analyzed the characteristics of atte-ntion function changes in each dimension,performed ex-ploratory cluster analysis to classify patients'attention function,and compared the differences in global cognition and motor function among subtypes.Results:There were 41 patients in the PD with cognitive impairment group,who showed significant differences from the PD with nor-mal cognition group and the normal control group in all at-tention dimension tests(P<0.05).In the 71 patients with PD and normal cognition,the errors in the trail making test and the interference amount of Stroop time con-sumption were significantly different from those of the normal control group(P<0.05).Exploratory cluster analy-sis suggested that PD patients might be classified into three types:high-transfer-high-allocation type,high-mainte-nance-balanced type,and low-transfer-low-selection type.Patients in the low-transfer-low-selection type had signifi-cantly lower global cognitive function and motor function than the other subtypes(P<0.05).Conclusion:Patients with early-to-mid stage PD show decline in attention selection and transfer functions,and other attention dimensions also decline as global cognitive function declines.The study observed that patients in the low-transfer-low-selection type had significantly lower global cognitive and motor functions than the other subtypes,providing preliminary evi-dence and a hypothesis worth testing for targeted assessment and treatment in future clinical work.