Nrf2双重调控帕金森病中氧化应激-铁死亡循环OA
Nrf2-mediated dual regulation of the oxidative stress-ferroptosis cycle in Parkinson's disease
帕金森病作为一种常见的神经退行性疾病,其核心病理特征为中脑黑质区多巴胺能神经元的进行性丧失,从而导致患者出现运动障碍等症状.近年来,氧化应激和铁代谢异常被认为是其发病机制中的核心因素.本文就氧化应激与铁死亡在帕金森病中的作用进行综述,并分析核因子E2相关因子2(Nrf2)通路的双刃剑作用,探讨精准调控Nrf2通路的策略,以期为帕金森病的治疗提供新的思路.
Parkinson's disease is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain,leading to motor dysfunction and other symptoms.In recent years,oxidative stress and abnormal iron metabolism have been identified as core factors in its pathogenesis.This review summarizes the roles of oxidative stress and ferroptosis in Parkinson's disease,analyzes the dual role of the nuclear factor erythroid 2-related factor 2(Nrf2)pathway,and discusses strategies for the precise regulation of the Nrf2 pathway,aiming to provide new insights for the treatment of Parkinson's disease.
罗婷;王秋婷;程卓霖;李双;聂政
成都医学院,四川 成都 610500成都医学院,四川 成都 610500成都医学院,四川 成都 610500成都医学院,四川 成都 610500成都医学院人体解剖学教研室/衰老机制与干预四川省重点实验室,四川 成都 610500
医药卫生
帕金森病氧化应激铁死亡细胞自噬Nrf2通路
Parkinson's diseaseoxidative stressferroptosisautophagyNrf2 pathway
《局解手术学杂志》 2026 (9)
756-760,5
成都医学院大学生创新训练项目(S202413705075)
评论