2025年山东省烟台市某县级市牛羊布鲁氏菌病病例对照研究OA

In order to identify the key transmission risk factors for bovine and ovine brucellosis in a county-level city of Yantai City,Shandong Province,a 1:4 matched case-control study was conducted based on the results of a cross-sectional survey carried out from September to October 2025.A total of 30 positive farms/households were assigned to the case group,and 126 negative farms/households were selected and matched as the control group.Data on 17 exposure factors were collected through questionnaires.Univariate analysis revealed that"introduction of animals in the past year"(OR=7.286,P＜0.001),"entry of vehicles transporting introduced animals into the farm"(OR=6.050,P=0.002),and"abortion in female animals in the past year"(OR=6.716,P＜0.001)were associated with brucellosis positivity.Multivariable Firth logistic regression identified that"entry of vehicles transporting introduced animals into the farm"(OR=6.312,P=0.009)and"entry of external veterinarians into the farm in the past six months"(OR=7.935,P=0.056)were potential risk factors,with a model AUC of 0.687.In conclusion,"entry of vehicles transporting introduced animals into the the farm"and"entry of external veterinarians into the farm in the past six months"were identified as key risk factors for brucellosis transmission,whereas a history of abortion in female animals was significant in univariate analysis.Accordingly,the following countermeasures were proposed for regions with smallholder farming systems:strengthening disinfection management of vehicle entry and biosecurity control for external veterinarians entry,improving quarantine for introduced animals,and incorporating abortion events in female animals into the early warning system.