胆汁酸与肠道菌群代谢相互作用及其对药物性胆汁淤积的影响OA

Drug-induced cholestasis(DIC)is an important subtype of drug-induced liver injury,with complex pathogenesis and a lack of effective treatment.The homeostasis imbalance of bile acids(BAs)is a key driving factor in the occurrence and development of DIC.Recent studies have found that dysbiosis of the gut microbiota is closely associated with BAs imbalance in DIC.This article reviews the impact of BAs imbalance on the development of DIC,focusing on the interaction mechanisms between BAs and the gut microbiota:on one hand,the gut microbiota regulates BAs metabolism,and on the other hand,BAs in turn shape the microbiota structure.Additionally,this interaction is analyzed in terms of its potential mechanisms in DIC progression,including inflammation activation,barrier disruption,and signaling pathway disorders.Finally,potential therapeutic strategies targeting the gut microbiota are discussed,aiming to provide insights and references for the basic research and clinical practice of DIC.