雌二醇类药物用于辅助生殖超说明书用药专家共识OA

With the rapid advancement of assisted reproductive technology(ART),an increasing number of infertile couples have achieved parenthood.Estradiol preparations play an irreplaceable role in key clinical procedures,including endometrial preparation for hormone replacement therapy-frozen-thawed embryo transfer(HRT-FET)and luteal phase support.However,the diversity of these agents and their routes of administration has led to prevalent off-label use and a lack of standardized guidance.To standardize the clinical use of estradiol in ART,the Consensus Development Group,following the World Health Organization(WHO)guideline development methodology,identified nine core clinical questions through a literature review and expert consultations.We systematically reviewed international and national databases to synthesize the best available evidence.Focusing on key aspects such as endometrial preparation protocols for HRT-FET,optimized management strategies for thin endometrium,indications and timing of estrogen administration in luteal phase support,and its application in GnRH antagonist protocols,the consensus ultimately formulated 15 recommendations.It clarified medication selection,routes of administration,dosage regimens,and treatment durations for various clinical scenarios.This consensus aimed to provide clinicians and pharmacists with practical,evidence-based references,facilitate the development of individualized treatment plans,optimize ART outcomes,ensure patient medication safety,and ultimately contribute to improving reproductive health services in China.