基于心肌声学造影评价心衰Ⅰ号方对急性心肌梗死后心力衰竭患者冠脉微循环的影响OA

Objective It is to evaluate the effect of Heart Failure No Ⅰ Decoction on coronary microvascular dysfunc-tion(CMD)in patients with heart failure after acute myocardial infarction(AMI)based on myocardial contrast echocardio-graphy(MCE).Methods Sixty patients with heart failure and CMD after AMI treated at the Department of Cardiology of Jiangsu Provincial Hospital of Traditional Chinese Medicine from June 2021 to February 2023 were randomly divided into an experimental group and a control group,with 30 cases in each group.The control group was treated with conventional west-ern medicine,while the experimental group was treated with Heart Failure No Ⅰ Decoction based on the therapy in the control group,both groups were treated for 8 weeks.The following parameters were compared between the two groups:myo-cardial perfusion score index(MPSI),wall motion score index(WMSI),number of segments with abnormal perfusion,segmental improvement rate,left ventricular ejection fraction(LVEF),left atrial diameter(LAD),left ventricular end-di-astolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular global longitudinal strain(LVGLS),traditional Chinese medicine(TCM)syndrome scores,and TCM syndrome efficacy.Results Compared with those before treatment,the MPSI and LVESD in both groups,as well as WMSI,LAD and LVEDD in the experimental group were significantly reduced(all P<0.05),the numbers of segments with abnormal perfusion in both groups were sig-nificantly reduced(all P<0.05),and the LVEF and LVGLS in both groups were significantly increased(all P<0.05);the MPSI,WMSI,number of segments with abnormal perfusion,the difference value of LVEF before and after treatment,and the improvement rate of segments with abnormal perfusion after treatment in the experimental group were all significant-ly higher than those in the control group(all P<0.05).After treatment,the scores of primary symptoms,secondary symp-toms,accompanied symptoms,tongue picture and pulse,and total scores in both groups were significantly lower than those before treatment(all P<0.05),and the differences of scores of palpitations and limb edema and total scores before and af-ter treatment in the experimental group were significantly higher than those in the control group(all P<0.05).The overall response rate of TCM syndrome in the experimental group was significantly higher than that in the control group[96.7%(29/30)vs 80.0%(24/30),P<0.05].Conclusion Heart Failure No Ⅰ Decoction can significantly improve left ven-tricular systolic function and CMD,and alleviate symptoms such as palpitations and limb edema in patients with heart fail-ure with CMD after AMI.