补肾益髓方对帕金森病运动症状及磷酸化α-突触核蛋白的影响OA
Decoction for tonifying kidney and replenishing marrow alleviates motor symptoms of Parkinson's disease via decreasing plasma level of phosphorylated α-Synuclein
目的 观察补肾益髓方对帕金森病(PD)患者运动症状及血浆磷酸化 α-突触核蛋白(p-α-syn)水平的影响,探究其可能作用机制.方法 将2021 年11 月—2022 年12 月就诊于北京中医药大学东方医院脑病一科的47 例 PD 患者随机分为2 组,对照组23 例给予抗 PD 西药治疗,观察组24 例给予抗 PD 西药及补肾益髓方治疗,2 组均治疗3 个月.比较2 组治疗前及治疗3个月后统一帕金森病评定量表(UPDRS)第二部分(UPDRS-Ⅱ)和第三部分(UPDRS-Ⅲ)评分,UPDRS-Ⅲ僵直、运动迟缓、震颤、中轴体征评分,肾虚髓减量表评分,血浆p-α-syn 水平和 p-α-syn/总蛋白比值.结果 治疗3 个月后,观察组 UPDRS-Ⅱ评分和 UPDRS-Ⅲ评分,UPDRS-Ⅲ僵直、运动迟缓、中轴体征评分,肾虚髓减量表评分,血浆 p-α-syn 水平和 p-α-syn/总蛋白比值均明显低于治疗前(P 均<0.05),UPDRS-Ⅲ震颤评分与治疗前比较差异无统计学意义(P>0.05);对照组各项评分及血浆 p-α-syn 水平和 p-α-syn/总蛋白比值与治疗前比较差异均无统计学意义(P 均>0.05);观察组治疗前后 UPDRS-Ⅱ评分差值、UPDRS-Ⅲ评分差值、UPDRS-Ⅲ中轴体征评分差值、肾虚髓减量表评分差值均明显高于对照组(P 均<0.05).观察组治疗 3 个月后的总有效率明显高于对照组[58.3%(14/24)比26.1%(6/23),P<0.05].结论 补肾益髓方可有效改善 PD 患者的运动症状,其机制可能与降低血浆 p-α-syn 水平有关.
Objective It is to observe the effect of decoction for tonifying kidney and replenishing marrow on motor symptoms and plasma level of phosphorylated α-synuclein(p-α-syn)in patients with Parkinson's disease,and to explore its possible mechanism of action.Methods Forty-seven patients with PD who were treated at the First Department of Neu-rology of Dongfang Hospital of Beijing University of Chinese Medicine from November 2021 to December 2022 were random-ly divided into two groups.23 patients in the control group were treated with western medication for against PD,while 24 patients in the observation group were treated with western medication against PD combined with decoction for tonifying kid-ney and replenishing marrow.Both groups were treated for 3 months.The scores of Parts Ⅱ of the Unified Parkinson's Disease Rating Scale(UPDRS-Ⅱ)and Parts Ⅲ(UPDRS-Ⅲ),as well as the scores of rigidity,bradykinesia,tremor,and axial sign in UPDRS-Ⅲ,the scores of Kidney Deficiency and Marrow Reduction Scale,plasma level of p-α-syn and p-α-syn/total protein ratio before treatment and after 3 months of treatment were compared between the two groups.Results After 3 months of treatment,the scores of UPDRS-Ⅱ and UPDRS-Ⅲ,as well as the scores of rigidity,bradykinesia and axial sign in UPDRS-Ⅲ,the scores of Kidney Deficiency and Marrow Reduction Scale,plasma level of p-α-syn and p-α-syn/total protein ratio were significantly lower than those before treatment in the observation group(all P<0.05),but there was no significant difference in the scores of tremor in UPDRS-Ⅲ between before and after treatment(P>0.05);there was no significant difference in the scores,plasma level of p-α-syn and p-α-syn/total protein ratio between before and after treatment in the control group(all P>0.05);the difference values in UPDRS-Ⅱ scores,UPDRS-Ⅲ scores,UP-DRS-Ⅲ axial sign scores,and Kidney Deficiency and Marrow Depletion Scale scores before and after treatment were all sig-nificantly higher than those in the control group(all P<0.05).The total effective rate in the observation group was higher than that in the control group[58.3%(14/24)vs 26.1%(6/23,P<0.05].Conclusion Decoction for tonifying kidney and replenishing marrow can effectively improve the motor symptoms in PD patients,and its mechanism may involve a re-duction in the level of p-α-syn in plasma.
张凯歌;徐萱;王垚;陈志刚
北京中医药大学东方医院,北京 100078北京中医药大学东方医院,北京 100078清华大学,北京 100084北京中医药大学东方医院,北京 100078
医药卫生
帕金森病磷酸化α-突触核蛋白补肾益髓方
Parkinson's diseasephosphorylated α-synucleindecoction for tonifying kidney and replenishing marrow
《现代中西医结合杂志》 2026 (15)
2069-2074,6
北京中医药大学校级项目(2020-JYB-ZDGG-119)国家中医药管理局十一五重点专科专病基金项目(040104001003)首都卫生发展科研专项项目(首发2018-2-4202)中央高水平中医医院临床科研业务费资助项目(DFRC-ZY-2024GJRC006)
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