骨水泥弥散类型影响椎体强化术后椎体生物力学的有限元分析OA
Finite element analysis of vertebral biomechanics after vertebral augmentation with different bone cement dispersion types
背景:椎体强化术治疗骨质疏松性椎体压缩骨折时对骨水泥填充剂量的研究比较广泛,但关于骨水泥不同弥散分布类型对治疗效果影响的相关性研究较少. 目的:运用三维有限元法分析不同骨水泥弥散分布类型对强化椎体生物力学特性的影响. 方法:建立T12骨质疏松性椎体压缩骨折的T9-L3椎体模型,通过数字化模拟经皮椎体后凸成形手术,将骨水泥注入T12椎体的不同区域,依据双侧椎弓根内侧缘线及脊柱正中垂线将T12椎体划分为4个区域(左侧椎弓根区、中线左侧区、中线右侧区及右侧椎弓根区,分别标记为1,2,3,4区);A组1-4区全部赋予骨水泥,B组2,3区赋予骨水泥,C组1,4区赋予骨水泥,D组1,2区赋予骨水泥,E组1区赋予骨水泥.固定模型L3下端,在T9上表面对椎体模型施加轴向应力150 N,同时施加10 N·m力矩模拟生理负荷状态下前后屈伸和左右侧屈运动;在T9上表面对椎体模型施加轴向应力500 N,同时施加15 N·m力矩模拟前后屈伸和左右侧屈运动,记录T12-L1椎体活动度、T12椎体最大米塞斯应力以及T11-12、T12-L1椎间盘米塞斯应力. 结果与结论:①术后T12椎体的活动度较术前均出现不同程度提升,A组T12椎体活动度最小,E组后伸和左旋时的T12椎体活动度变化略低于B组;T12椎体米塞斯应力在椎体强化术后显著下降,B组前屈、后伸、左屈、右屈运动时的T12椎体米塞斯应力下降最明显,应力极值分别为13.840,29.450,49.504,50.020 MPa,C组左旋和右旋运动时的T12椎体米塞斯应力下降最为明显,分别为33.661,33.450 MPa;椎体强化术后,T11-T12椎间盘米塞斯应力在运动时呈现降低趋势,T12-L1椎间盘米塞斯应力在运动时呈现增加趋势.综合数据表明,T12椎体在以B类骨水泥弥散分布进行椎体强化时可显著降低椎体承受应力,T11-T12椎间盘米塞斯应力减低由下方的T12-L1椎间盘承担了其部分应力,减小了邻近椎体发生再骨折的风险.②结果表明,椎体强化术中均匀弥散分布的骨水泥可以更好地降低椎体所承受的米塞斯应力,最大限度地维持椎体术后稳定性,减小术后伤椎再发骨折的风险.
BACKGROUND:Studies on bone cement filling dosage in vertebral augmentation for osteoporotic vertebral compression fractures are relatively extensive,but there is limited research on the correlation between different bone cement dispersion patterns and their impact on treatment outcomes. OBJECTIVE:To analyze the influence of different bone cement dispersion types on the biomechanical properties of augmented vertebrae using the three-dimensional finite element method. METHODS:A T9-L3 vertebral model was established for T12 osteoporotic vertebral compression fracture.Percutaneous kyphoplasty was digitally simulated,and bone cement was injected into different regions of the T12 vertebral body.Based on the medial borders of bilateral pedicles and the midline of the spine,the T12 vertebra was divided into four regions(left pedicle region,left midline region,right midline region,and right pedicle region,labeled as regions 1,2,3,and 4,respectively).Group A:Bone cement was assigned to all regions 1-4;Group B:regions 2 and 3 were assigned bone cement;Group C:regions 1 and 4 were assigned bone cement;Group D:regions 1 and 2 were assigned bone cement;Group E:region 1 was assigned bone cement.The lower end of the L3 model was fixed.On the upper surface of T9,an axial stress of 150 N was applied to the vertebral model,together with a torque of 10 N·m to simulate flexion-extension and lateral bending under physiological load.On the upper surface of T9,an axial stress of 500 N was applied to the vertebral model,together with a torque of 15 N·m to simulate flexion-extension and lateral bending.The range of motion of the T12-L1 vertebra,the maximum Mises stress of the T12 vertebra,and the Mises stress of the T11-12 and T12-L1 intervertebral discs were recorded. RESULTS AND CONCLUSION:The range of motion of the T12 vertebra after surgery increased to varying degrees compared with before surgery.Group A had the smallest range of motion of the T12 vertebra,and the changes in the range of motion of the T12 vertebra during extension and left rotation in Group E were slightly lower than those in Group B.The Mises stress of the T12 vertebra decreased significantly after vertebral augmentation.The decrease in the Mises stress of the T12 vertebra during flexion,extension,left bending,and right bending was most obvious in Group B,with peak stress values of 13.840,29.450,49.504,and 50.020 MPa,respectively.The decrease in the Mises stress of the T12 vertebra during left rotation and right rotation was most obvious in Group C,with stress values of 33.661 and 33.450 MPa,respectively.After vertebral augmentation,the Mises stress of the T11-T12 intervertebral disc showed a decreasing trend during movement,while the Mises stress of the T12-L1 intervertebral disc showed an increasing trend during movement.Comprehensive data indicate that when T12 vertebral augmentation is performed with the bone cement dispersion pattern of Group B,the stress borne by the vertebra is significantly reduced.Part of the reduced Mises stress of the T11-T12 intervertebral disc is borne by the underlying T12-L1 intervertebral disc,reducing the risk of re-fracture in adjacent vertebrae.These findings indicate that uniformly dispersed bone cement in vertebral augmentation can better reduce the Mises stress borne by the vertebra,maximize postoperative vertebral stability,and reduce the risk of recurrent fracture of the injured vertebra after surgery.
刘少华;呼斯乐;高文瑞;白明
内蒙古医科大学,内蒙古自治区呼和浩特市 010110内蒙古医科大学,内蒙古自治区呼和浩特市 010110内蒙古医科大学第二附属医院,内蒙古自治区呼和浩特市 010000内蒙古医科大学第二附属医院,内蒙古自治区呼和浩特市 010000
医药卫生
骨质疏松胸腰段骨折骨水泥椎体强化术骨水泥弥散分布类型有限元分析
osteoporosisthoracolumbar fracturebone cementvertebral augmentationbone cement dispersion typefinite element analysis
《中国组织工程研究》 2026 (30)
7815-7822,8
内蒙古医科大学面上项目(YKD2022MS024),项目负责人:白明 General Program of Inner Mongolia Medical University,No.YKD2022MS024(to BM)
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