维持性血液透析合并肌少症的中医证候研究及相关影响因素分析OA

[Objective]To investigate the characteristics of traditional Chinese medicine(TCM)syndrome patterns and their associated influencing factors in maintenance hemodialysis(MHD)patients complicated with sarcopenia.[Methods]In this single-center cross-sectional study,199 MHD patients were enrolled.Based on the 2019 Asian Working Group for Sarcopenia(AWGS)diagnostic criteria,patients were divided into a sarcopenia group and a non-sarcopenia group.Clinical data and TCM four diagnostic data were collected,and TCM syndrome patterns and identify associated risk factors were used to be statistical analysis.[Results]The prevalence rate of sarcopenia in this MHD cohort was 30.2%.Compared to the non-sarcopenia group,patients in the sarcopenia group were older,had a higher comorbidity index and prevalence of cerebral infarction,while exhibiting significantly lower body mass index(BMI),a lower proportion engaging in regular exercise,and reduced handgrip strength(P<0.05).Regarding TCM syndrome patterns,the primary pattern in both groups was spleen-kidney qi deficiency syndrome.The sarcopenia group had a significantly higher proportion of damp-turbidity syndrome(P<0.05),while the non-sarcopenia group had a higher proportion of blood stasis syndrome(P<0.05).Analysis of syndrome scores revealed that scores for spleen-kidney qi deficiency syndrome,spleen-kidney yang deficiency syndrome,and blood stasis syndrome were all significantly higher in the sarcopenia group compared to the non-sarcopenia group(P<0.05).Multivariate Logistic regression analysis indicated that advanced age,male gender and lack of exercise were risk factors for sarcopenia,while higher BMI,stronger handgrip strength and blood stasis syndrome were protective factors.[Conclusion]MHD patients with sarcopenia predominantly present with spleen-kidney qi deficiency as the primary pattern and internal obstruction by damp-turbidity as the secondary manifestation.Clinically,factors such as advanced age,male gender,and lack of exercise may increase the risk of sarcopenia in MHD patients.