电针抗抑郁作用的影像及分子机制的研究进展OA

Depression is a prevalent chronic and severe mental disorder characterized by structural and functional abnormalities in multiple brain regions that regulate emotion,cognition,and reward processing,alongside multiple molecular pathological alterations.As a non-pharmacological intervention,electroacupuncture has exhib-ited considerable therapeutic potential for depression treatment.Its antidepressant effects are not limited to a single brain region or molecular target;Instead,it exerts multi-level antidepressant actions by modulating abnormal brain activity and functional connectivity,which in turn influences neuroplasticity,inflammatory responses,and neurotransmitter release.Focusing on brain imaging findings and the molecular mechanisms underlying brain region-specific alterations,this article reviews functional brain abnormalities in depression and the neurobiological mechanisms underlying electroacupuncture intervention,with the aim of providing a theoretical foundation for mechanistic research and clinical application of electroacupuncture for depression treatment.