QT间期离散度、心肌酶与急性心肌梗死患者冠脉狭窄程度的关联性及预测价值OA

Objective:Analysis of the correlation between QT dispersion(QTD)combined with creatine kinase MB(CK-MB),myoglobin(Mb),and cardiac troponin I(cTnI)with severe coronary artery stenosis in patients with acute myocardial infarction(AMI),and evaluation of its predictive value for coronary artery stenosis.Methods:Eighty patients with acute myocardial infarction(AMI)admitted to our hospital were enrolled in this study,and divided into a severe group(score≥60,n=29)and a moderate-to-mild group(score＜60,n=51)based on the Gensini score.Levels of CK-MB,Mb,and cTnI were measured by enzyme-linked immunosorbent assay(ELISA),and electrocardio-grams were recorded using a 12-lead ECG.Clinical characteristics of AMI patients with different severities of coro-nary stenosis were compared.Spearman correlation analysis was used to assess the association between the degree of coronary stenosis and QTD along with serological indicators.ROC curves were employed to evaluate their predictive value for coronary stenosis in AMI patients.Results:The severe group had higher Gensini scores,CK-MB,Mb,cTnI,and QTD than the moderate to mild group(all P＜0.05),while there was no significant difference in other character-istics between the two groups(P＞0.05).Spearman showed that the Gensini score of AMI patients was positively correlated with CK-MB,Mb,cTnI,and QTD(r=0.641、0.737、0.445、0.464,all P＜0.05).There were also signifi-cant positive correlations among the serological indicators(all P＜0.05).The ROC curve showed that the sensitivity and specificity of CK-MB,Mb,cTnI,and QTD in jointly evaluating the severity of coronary stenosis in AMI patients were 85.78％and 80.47％,respectively,with an AUC of 0.923,all higher than CK-MB、Mb、cTnI、QTD individual evaluation.Conclusion:QTD,CK-MB,Mb,and cTnI are positively correlated with the degree of coronary artery steno-sis,and their combined detection can enhance the predictive efficacy for coronary stenotic lesions.