帕金森病阳虚肝郁病机研究OACHSSCD
Yang Deficiency and Liver Depression in Parkinson's Disease
现今研究发现,帕金森病位在脑,表现为运动与非运动双重症状,集中于中老年群体.中医学将其归属于"颤证"范畴,或兼见他证.古今医家主要从肝肾阴虚、虚风内动来论治.但笔者认为帕金森病与阳虚关系密切,运动与非运动症状皆与阳气的盛衰和运行有关.因此,本文突破传统的帕金森病阴虚风动理论,认为帕金森病以脾肾阳虚为本,肝气郁滞为标,且阳虚气郁是贯穿整个病情的基本病机.在此基础之上,治以温阳解郁,方选《伤寒杂病论》中四逆汤合四逆散,以期为临床诊疗提供新的思路.
Current research has found that Parkinson's disease(PD)is located in the brain and manifests as both motor and non-motor symptoms,predominantly affecting middle-aged and older adults.In traditional Chinese medicine(TCM),PD is classified un-der the category of"tremor syndrome"or may coexist with other syndromes.Ancient and modern TCM physicians have primarily discussed its treatment from the perspectives of liver-kidney yin deficiency and deficiency-generated wind stirring.However,the au-thor believes that PD is closely associated with yang deficiency,and that both motor and non-motor symptoms are related to the exu-berance or decline and movement of yang qi.Therefore,this article challenges the traditional theory of yin deficiency and wind stir-ring in PD and proposes that spleen-kidney yang deficiency is the root,while liver qi stagnation is the manifestation.Moreover,yang deficiency and qi stagnation constitute the fundamental pathogenesis throughout the entire disease course.On this basis,treatment is based on warming yang and relieving stagnation,with Sini Decoction combined with Sini Powder,as recorded in the Treatise on Cold Damage and Miscellaneous Diseases,selected as the formula,with the aim of providing a new approach to the clinical diagnosis and treatment of PD.
罗少涵;潘明敏;雷童;于慧杰;孟晓莹;李想;岳广欣
中国中医科学院中医基础理论研究所,北京,100010中国中医科学院中医基础理论研究所,北京,100010中国中医科学院中医基础理论研究所,北京,100010中国中医科学院中医基础理论研究所,北京,100010中国中医科学院中医基础理论研究所,北京,100010中国中医科学院中医基础理论研究所,北京,100010中国中医科学院中医基础理论研究所,北京,100010
医药卫生
帕金森病阳虚气郁四逆汤四逆散
Parkinson's diseaseDeficiency of yangQi stagnationSini DecoctionSini Powder
《世界中医药》 2026 (12)
2218-2223,6
国家自然科学基金面上项目(82174251)北京市自然科学基金面上项目(7232300)中国中医科学院科技创新工程中医理论传承与创新专项(KYG-202406).
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