基于"痰浊"理论探讨氧化应激与慢性阻塞性肺疾病的关系OACHSSCD

Chronic obstructive pulmonary disease(COPD)is a chronic airway disease closely associated with oxidative stress.In traditional Chinese medicine(TCM)theory,COPD is characterized by deficiency of the root and excess at the manifestation.Defi-ciency of the lung,spleen,and kidney leads to abnormal fluid metabolism and the formation of phlegm pathogens,with"phlegm tur-bidity"regarded as a core pathological factor that affects the progression and outcome of COPD.Studies have shown that the patho-logical mechanisms of"phlegm turbidity"are consistent with those of oxidative stress.Both are characterized by an imbalance in the internal environment of the body.Specifically,"phlegm"originates from an imbalance of yin and yang in the Zang-fu organs,re-sulting in abnormal fluid metabolism,whereas oxidative stress results from an imbalance between the oxidation and antioxidant sys-tems."Phlegm turbidity"has pathogenic characteristics of being ubiquitous and producing complex and variable symptoms,which are highly similar to the multisystem damage and pathological state driven by chronic inflammation induced by oxidative stress.Based on the theory of"phlegm turbidity",this article systematically elaborates on the key role of oxidative stress in COPD and proposes that treating"phlegm"through the lung,spleen,and kidney may regulate oxidative stress in a multitarget and systemic manner,thereby controlling the progression of COPD.This perspective aims to provide a new theoretical basis and therapeutic ap-proach for intervening in the oxidative stress state of COPD and delaying disease progression through the TCM treatment of"phlegm".