犬尿氨酸途径代谢失衡:抑郁症发病机制及抗抑郁药物研发新思路OA
Metabolic Imbalance of the Kynurenine Pathway:The Pathogenesis of Depression and New Ideas for the Development of Antidepressant Drugs
抑郁症是一种高度异质性的精神疾病,其特征主要是持续的情绪低落和快感缺失,严重影响患者的社会功能和生活质量.近年来,随着对抑郁症的神经炎症机制研究的深入,作为色氨酸重要代谢途径的犬尿氨酸途径受到广泛关注.该途径的代谢产物主要包括喹啉酸和犬尿酸,二者相对水平的失衡被证明与抑郁症发病密切相关.然而,目前尚不清楚这种失衡是如何发生以及如何导致抑郁症状的.因此,本文综述了犬尿氨酸途径在抑郁症病理机制中的作用及相关药物的调节机制,旨在从神经炎症角度进一步揭示抑郁症的发病机制,并为抗抑郁药物的研发提供新思路.
Depression is a highly heterogeneous mental disorder characterized primarily by persistent low mood and anhedonia,which significantly impair patients'social functioning and quality of life.In recent years,with the deepening of research into the neuroinflammatory mechanisms of depression,the kynurenine pathway,a key metabolic pathway of tryptophan has garnered significant attention.The metabolic products of this pathway primarily include quinolinic acid and kynurenic acid,and imbalances in their relative levels have been shown to be closely associated with the onset of depression.However,the mechanisms underlying this imbalance and its contribution to depressive symptoms remain unclear.This review examines the role of the kynurenine pathway in the pathophysiology of depression and the regulatory mechanisms of related drugs,aiming to further elucidate the pathogenesis of depression from a neuroinflammatory perspective and provide new insights for the development of antidepressant medications.
黄金清;祝有阳;赵连娜;牛志超;杨雪娇;雷娜;解宇环
云南中医药大学中药学院 昆明 650500云南中医药大学第一临床医学院 昆明 650500云南中医药大学中药学院 昆明 650500云南中医药大学基础医学院 昆明 650500云南中医药大学中药学院 昆明 650500云南中医药大学基础医学院 昆明 650500云南中医药大学科技处 昆明 650500
医药卫生
抑郁症发病机制犬尿氨酸途径犬尿酸喹啉酸
DepressionPathogenesisKynurenine pathwayKynurenic acidQuinolinic acid
《世界科学技术-中医药现代化》 2026 (8)
2493-2505,13
云南省科技人才和平台计划(202105AG070012):基于外侧缰核NMDAR/BDNF信号通路的丁香挥发油快速抗抑郁作用的机制研究,负责人:黄金清.
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