艾草多糖对断奶仔猪血清生化指标、内脏组织病理和脾脏抗氧化能力的影响OA

This experiment was conducted to investigate the effects of Artemisia argyi polysaccharide(AAP)on organ indices,serum biochemical indicators,visceral histopathology and splenic antioxidant capacity of weaned piglets.A total of 35 healthy 28-day-old Duroc×Landrace×Yorkshire weaned piglets(boars)with an initial body weight of(7.00±0.21)kg were selected and randomly assigned to one of five dietary treat-ments with seven replicate pens(one piglet per replicate).The piglets in the control group were fed a basal diet,while the experimental groups received the basal diet supplemented with 500,1 000,1 500,and 2 000 mg/kg AAP for a 28 d experimental period.The results showed as fol-lows:① increasing the dietary AAP level resulted in a linear tendency(0.05<P<0.10)in the pancreatic index and a quadratic trend(0.05<P<0.10)in the gall-bladder index of weaned piglets.② Compared with the control group,the 1 000 mg/kg AAP group signifi-cantly increased the serum contents of total protein(TP)and albumin(ALB)(P<0.05).Additionally,the ala-nine aminotransferase(ALT)and aspartate aminotransferase(AST)activities in serum showed a significant quadratic effect with increasing AAP supplementation(P<0.05).③ Congestion and hemorrhage were observed in both the renal cortex and medulla of piglets in the control group,along with vacuolar degenera-tion and inflammatory cell infiltration in renal tubular cells.In contrast,these pathological alterations were alleviated to varying degrees in the AAP-supplemented groups.④ Compared with the control group,the 1 000 mg/kg AAP group significantly increased splenic total superoxide dismutase(T-SOD)activity(P<0.05),while both the 1 000 and 1 500 mg/kg AAP groups significantly reduced splenic malondialdehyde(MDA)concentration(P<0.05).In conclusion,dietary supplementation with AAP can improve serum protein metabolism,enhance splenic antioxidant capacity,and effectively alleviate visceral histopathology damage induced by weaning stress in piglets.Under the conditions of this experiment,the optimal supplementation level of AAP is 1 000 mg/kg.