热敏灸联合八珍汤加味治疗化疗后癌因性疲乏的疗效观察OA
Efficacy observation of heat-sensitive moxibustion combined with modified Ba Zhen decoction for cancer-related fatigue after chemotherapy
目的 观察热敏灸联合八珍汤加味治疗胃癌化疗后癌因性疲乏的临床疗效.方法 将 106 例胃癌化疗后癌因性疲乏患者采用区组随机化法分为观察组和对照组,每组53例.对照组给予八珍汤加味治疗,观察组在其基础上给予热敏灸治疗.观察两组治疗前后的主要疗效指标包括相关量表评分[癌症疲乏量表(cancer fatigue scale,CFS)、Piper 疲乏修订量表(Piper fatigue scale-revised,PFS-R)和简明疲劳量表(brief fatigue inventory,BFI)],免疫功能指标及血清肿瘤标志物[癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原72-4(carbohydrate antigen 72-4,CA72-4)和糖类抗原 19-9(carbohydrate antigen 19-9,CA19-9)],次要疗效指标(中医证候积分、血清胃肠激素水平)及临床疗效.结果 两组治疗后 CFS、PFS-R和 BFI 评分均较治疗前降低(P＜0.05),且观察组低于对照组(P＜0.05).两组治疗后 CD3﹢T细胞、CD4﹢T 细胞和 CD8﹢T细胞占比均改善(P＜0.05),且观察组优于对照组(P＜0.05).两组治疗后血清 CEA、CA72-4 和 CA19-9 水平均较治疗前降低(P＜0.05),且观察组低于对照组(P＜0.05).两组治疗后中医证候积分均较治疗前降低(P＜0.05),且观察组低于对照组(P＜0.05).两组治疗后血清胃泌素、胃动素水平均较治疗前升高(P＜0.05),血管活性肠肽水平均较治疗前降低(P＜0.05),且观察组优于对照组(P＜0.05).观察组总有效率为 89.8%,显著高于对照组的 81.6%(P＜0.05).结论 热敏灸联合八珍汤加味治疗胃癌化疗后癌因性疲乏患者疗效显著.
Objective To observe the clinical efficacy of heat-sensitive moxibustion combined with modified Ba Zhen decoction in the treatment of cancer-related fatigue(CRF)in patients with gastric cancer after chemotherapy.Method A total of 106 patients with CRF after chemotherapy for gastric cancer were assigned by block randomization to an observation group and a control group,with 53 patients in each group.The control group received modified Ba Zhen decoction,while the observation group additionally received heat-sensitive moxibustion.Primary outcome measures included fatigue-related scales,namely the cancer fatigue scale(CFS),Piper fatigue scale-revised(PFS-R),and brief fatigue inventory(BFI);immune function indicators;and serum tumor markers,including carcinoembryonic antigen(CEA),carbohydrate antigen 72-4(CA72-4),and carbohydrate antigen 19-9(CA19-9).Secondary outcome measures included traditional Chinese medicine(TCM)syndrome scores,serum gastrointestinal hormone levels,and clinical efficacy.Result After treatment,CFS,PFS-R,and BFI scores were significantly reduced in both groups compared with baseline(P＜0.05),and the reductions were greater in the observation group than in the control group(P＜0.05).The proportions of CD3﹢ T cells,CD4﹢ T cells,and CD8﹢ T cells improved significantly in both groups after treatment(P＜0.05),with greater improvements in the observation group(P＜0.05).Serum levels of CEA,CA72-4,and CA19-9 decreased significantly in both groups after treatment compared with baseline(P＜0.05),and were lower in the observation group than in the control group(P＜0.05).TCM syndrome scores were significantly reduced in both groups after treatment(P＜0.05),with lower scores in the observation group(P＜0.05).Serum gastrin and motilin levels increased significantly after treatment in both groups(P＜0.05),whereas vasoactive intestinal peptide levels decreased significantly(P＜0.05);all changes were more pronounced in the observation group(P＜0.05).The overall response rate was 89.8%in the observation group,significantly higher than the 81.6%in the control group(P＜0.05).Conclusion Heat-sensitive moxibustion combined with modified Ba Zhen decoction demonstrates significant efficacy in patients with cancer-related fatigue following chemotherapy for gastric cancer.
姚沁;孙兵;倪璟;王超雄;黄坚
金华市中医医院,金华 321017金华市中医医院,金华 321017金华市中医医院,金华 321017金华市中医医院,金华 321017金华市中医医院,金华 321017
医药卫生
热敏灸八珍汤肿瘤癌因性疲乏免疫功能生物标志物,肿瘤
Heat-sensitive moxibustionBa Zhen decoctionNeoplasmsChemotherapyCancer-related fatigueBiomarkers,Tumor
《上海针灸杂志》 2026 (9)
973-979,7
金华市科学技术研究计划项目(2021-4-293)
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