瓜石汤治疗阴虚胃热型非肥胖型多囊卵巢综合征临床研究OA
Clinical study of Guashi decoction in the treatment of non-obese polycystic ovary syndrome of yin deficiency and stomach heat pattern
目的:探讨瓜石汤对阴虚胃热型非肥胖型多囊卵巢综合征(PCOS)患者的临床效果.方法:选择阴虚胃热型非肥胖型PCOS患者92例,按随机数字表法分为对照组和研究组,各46例.两组均给予基础生活干预,对照组给予达英-35 口服,研究组在对照组基础上采用瓜石汤治疗,疗程均为3个月经周期.比较两组临床疗效、中医证候积分、血清性激素、糖代谢指标、卵巢超声指标及不良反应变化.结果:研究组总有效率高于对照组(P＜0.05);研究组月经不调、口干咽燥、手足心热、心烦失眠、多梦易醒、腰膝酸软、潮热盗汗低于对照组(P＜0.05);研究组血清促黄体生成素(LH)、LH/促卵泡刺激素(FSH)比值、睾酮(T)指标低于对照组(P＜0.05);研究组空腹血糖(FPG)与空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)指标低于对照组(P＜0.05);研究组卵巢体积、窦卵泡数低于对照组(P＜0.05);两组总不良反应发生率比较无统计学差异(P＞0.05).结论:瓜石汤治疗阴虚胃热型非肥胖型多囊卵巢综合征效果显著,可有效改善临床症状、调节性激素水平及糖代谢紊乱,优化卵巢形态,且安全性良好.
Objective:To investigate the clinical effect of Guashi decoction in patients with non-obese polycystic ovary syndrome(PCOS)of yin deficiency and stomach heat pattern.Methods:A total of 92 patients with non-obese PCOS of yin deficiency and stomach heat pattern were selected.All participants were randomly assigned to the con-trol group and the research group by the random number table method,with 46 cases in each group.Both groups re-ceived basic lifestyle interventions.The control group was administered Diane-35 orally,while the research group re-ceived Guashi decoction in addition to the interventions given to the control group.The course of treatment for all groups was three menstrual cycles.Clinical efficacy,TCM syndrome scores,serum sex hormones,glucose metabolism markers,ovarian ultrasound findings,and adverse reactions were compared among the two groups.Results:The over-all effective rate in the research group was significantly superior to that in the control group(P＜0.05).The scores for irregular menstruation,dry mouth and throat,hot palms and soles,irritability and insomnia,dream-disturbed sleep and easy awakening,soreness and weakness of waist and knees,and tidal fever and night sweats in the research group were lower than those in the control group(P＜0.05).The levels of luteinizing hormone(LH),LH/follicle-stimula-ting hormone(FSH)ratio,and testosterone(T)in the research group were lower than those in the control group(P＜0.05).The levels of fasting plasma glucose(FPG),fasting insulin(FINS),and homeostasis model assessment of insulin resistance(HOMA-IR)in the research group were lower than those in the control group(P＜0.05).The research group had lower ovarian volume and fewer antral follicles than the control group(P＜0.05).No statistically significant difference in overall incidence of adverse reactions was found among the two groups(P＞0.05).Conclusion:Guashi decoction is highly effective in the treatment of non-obese PCOS of yin deficiency and stomach heat pattern.It can markedly alleviate TCM syndrome,adjusts sex hormone levels and glucose metabolism,improves ovarian mor-phology,and is well-tolerated.
刘春芬;易蕾;黎娇平;李雪梅;岑芳
南宁市中医医院,广西南宁 530001南宁市中医医院,广西南宁 530001南宁市中医医院,广西南宁 530001南宁市中医医院,广西南宁 530001南宁市中医医院,广西南宁 530001
医药卫生
非肥胖型多囊卵巢综合征瓜石汤阴虚胃热型性激素中医证候胰岛素抵抗
Non-obese polycystic ovary syndromeGuashi decoctionYin deficiency and stomach heat patternSex hormonesTCM syndromeInsulin resistance
《陕西中医》 2026 (9)
1202-1206,5
广西壮族自治区中医药管理局自筹经费科研课题(GXZYA20220345)
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