关节腔注射富血小板血浆联合微骨折技术对膝关节骨关节炎患者疼痛程度及膝关节功能的影响OA
Effect of intraarticular injection of platelet-rich plasma combined with micro fracture technique on pain severity and knee function in patients with knee osteoarthritis
目的 探讨关节腔富血小板血浆(PRP)注射联合微骨折技术对膝关节骨关节炎(KOA)患者疼痛程度及膝关节功能恢复的影响.方法 选取沧州市中心医院2024年1-12月收治的KOA患者106例,随机数字表法分为观察组(n=53)与对照组(n=53).观察组给予关节腔PRP注射联合微骨折技术治疗,对照组给予微骨折技术治疗,比较两组西安大略麦克马斯特大学骨关节炎指数(WOMAC)评分、疼痛视觉模拟评分法(VAS)评分、膝关节活动度、膝关节功能(Lysholm-Ⅱ量表、Rasmussen量表)、影像学评估[磁共振成像观察软骨修复组织评分系统2.0(MOCART 2.0)评分]、血常规指标[血小板计数(PLT)、白细胞计数(WBC)水平]以及并发症发生情况.结果 治疗后3个月,观察组WOMAC评分、疼痛VAS评分低于对照组,膝关节功能Lysholm-Ⅱ及Rasmussen量表评分高于对照组,膝关节活动度大于对照组(P＜0.05).治疗后6个月,观察组MOCART 2.0评分高于对照组(P＜0.05).两组治疗后1个月外周血WBC、PLT水平比较差异无统计学意义(P＞0.05).观察组与对照组并发症发生率[5.66％(3/53)vs.9.43％(5/53)]比较差异无统计学意义(P＞0.05).结论 关节腔PRP注射联合微骨折技术能显著缓解KOA患者疼痛程度,有利于软骨修复,改善患者膝关节功能,增大活动度,且安全性较好.
Objective To investigate the effects of intraarticular injection of platelet-rich plasma(PRP)combined with micro fracture technique on the pain severity and functional recovery of knee joints in patients with knee osteoarthritis(KOA).Methods A total of 106 patients with KO A admitted to Cangzhou Central Hospital from January to December 2024 were selected and divided into the observation group(n=53)and the control group(n=53)using the random number table method.The observation group was treated with intraarticular injection of PRP combined with micro fracture technique,while the control group was treated with microfracture technique alone.The Western Ontario McMaster Universities Osteoarthritis Index(WOMAC)score,Visual Analogue Scale(VAS)pain score,knee joint range of motion(ROM),knee joint function(Lysholm-Ⅱ scale,Rasmussen scale),imaging assessment[Magnetic Resonance Observation Score System for Cartilage Repair 2.0(MOCART 2.0)score],complete blood count parameters[platelet count(PLT),white blood cell count(WBC)],and the occurrence of complications were compared between the two groups.Results At three months after the treatment,the WOMAC score and VAS pain scores of the observation group were lower than those of the control group,while the Lysholm-Ⅱand Rasmussen scale scores of the knee joint function were higher than those of the control group,and the ROM of the knee joint was greater than that of the control group(P＜0.05).At six months after the treatment,the MOCART 2.0 score of the observation group was higher than that of the control group(P＜0.05).There was no significant difference in the peripheral blood WBC and PLT levels between the two groups at 1 month after treatment(P＞0.05),nor significant difference in the incidence of complications between the observation group and the control group[5.66％(3/53)vs.9.43％(5/53)](P＞0.05).Conclusion Intraarticular injections of PRP combined with microfracture technique can significantly alleviate the pain of patients with KO A,facilitate cartilage repair,improve the knee joint function of patients,increase the ROM,and have good safety.
刘永庆;桑卫华;苏柯;杨帆;王军
沧州市中心医院关节外二科,河北沧州 061000沧州市中心医院关节外二科,河北沧州 061000沧州市中心医院关节外二科,河北沧州 061000沧州市中心医院关节外二科,河北沧州 061000沧州市中心医院关节外二科,河北沧州 061000
膝关节骨关节炎微骨折技术富血小板血浆疼痛骨关节炎指数膝关节功能
knee osteoarthritismicrofracture technologyplatelet-rich plasmapainosteoarthritis indexknee function
《临床误诊误治》 2026 (18)
48-54,7
2025年度河北省医学科学研究课题计划项目(20250264)
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