慢加急性肝衰竭动物模型的研究进展:从两阶段构建到三阶段全病程模拟OA

Acute-on-chronic liver failure(ACLF)is a severe clinical syndrome characterized by acute decompensation of liver function,extrahepatic organ injury,and a high short-term mortality rate,with a complex pathogenesis that has not yet been fully clarified.Animal models of ACLF play a crucial role in disease research,since they not only provide a solid foundation for mechanistic studies,but also offer experimental evidence for clinical practice,thereby helping to promote advances in diagnosis and treatment.This article systematically reviews the commonly used animal models of ACLF,compares the establishment methods,pathophysiological characteristics,advantages,and limitations of different models,and discusses the latest research advances in animal models and innovative therapeutic strategies in the field,in order to provide a reference for further optimization,standardization,and application of animal models for ACLF.