血清sEng、Fis1水平与多发伤患者病情严重程度和多器官功能障碍综合征的关系OA

Objective To investigate the associations of serum soluble endoglin(sEng)and mitochondrial fission 1 protein(Fis1)levels with disease severity and multiple organ dysfunction syndrome(MODS)in pa-tients with multiple trauma(MT),and to evaluate their predictive performance for MODS.Methods A total of 205 patients with MT admitted to the hospital from February 2023 to August 2025 were enrolled in the MT group,and 146 healthy individuals who underwent physical examinations at the same hospital during the same period were enrolled in the control group.Serum sEng and Fis1 levels were measured in all participants using enzyme-linked immunosorbent assay(ELISA).According to disease severity,the patients with MT were di-vided into mild,moderate,severe,and critical MT groups.Spearman correlation analysis was performed to as-sess the correlations of serum sEng and Fis1 levels with disease severity in patients with MT.Based on wheth-er MODS occurred within 7 d after admission,the patients were divided into a MODS group and a non-MODS group.Multivariate Logistic regression analysis was performed to identify factors influencing the development of MODS in patients with MT.Receiver operating characteristic(ROC)curve analysis was performed to eval-uate the predictive performance of serum sEng and Fis1 alone and in combination for the development of MODS in patients with MT.Results Serum sEng and Fis1 levels were significantly higher in the MT group than those in the control group(P<0.001).Among the 205 patients with MT,67 had mild MT,86 had mod-erate MT,32 had severe MT,and 20 had critical MT.Serum sEng and Fis1 levels increased progressively across the mild,moderate,severe,and critical MT groups(P<0.001).Serum sEng and Fis1 levels were posi-tively correlated with disease severity in patients with MT(rs=0.778 and 0.751,respectively;both P<0.001).The incidence of MODS among the 205 patients with MT was 36.10%(74/205).Multivariate Logis-tic regression analysis showed that severe disease(OR=5.222,95%CI:2.150-12.687,P<0.001),critical disease(OR=11.213,95%CI:4.112-30.573,P<0.001),an increased Acute Physiology and Chronic Health Evaluation Ⅱ score(OR=1.088,95%CI:1.002-1.182,P=0.045),blood transfusion(OR=5.662,95%CI:1.551-20.674,P=0.009),tracheal intubation(OR=5.936,95%CI:1.300-27.113,P=0.022),an ele-vated serum sEng level(OR=9.051,95%CI:3.432-23.871,P<0.001),and an elevated serum Fis1 level(OR=2.124,95%CI:1.411-3.196,P<0.001)were independent risk factors for the development of MODS in patients with MT.The area under the curve(AUC)for the combination of serum sEng and Fis1 levels in predicting MODS was 0.908,which was greater than those for serum sEng and Fis1 levels alone(0.836 and 0.827,respectively;P<0.001).Conclusion Elevated serum sEng and Fis1 levels are associated with in-creased disease severity in patients with MT and are independent risk factors for the development of MODS.The combination of serum sEng and Fis1 levels provides superior predictive performance for MODS.