血清HDAC3、TSG-6、FSTL1对不稳定型心绞痛患者预后不良的预测价值OA

Objective To investigate the predictive value of serum histone deacetylase 3(HDAC3),tumor necrosis factor-α stimulating factor-6(TSG-6)and follistatin-like protein 1(FSTL1)for poor prognosis in pa-tients with unstable angina pectoris(UAP).Methods A total of 130 patients with UAP who underwent per-cutaneous coronary intervention in the hospital from May 2023 to May 2025 were selected as the observation group,and 133 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.Enzyme-linked immunosorbent assay was used to detect the serum levels of HDAC3,TSG-6 and FSTL1 in all subjects.According to the degree of coronary artery disease score,UAP pa-tients were divided into low-risk group,intermediate-risk group and high-risk group.Baseline data of all pa-tients were collected.All patients were followed up for 3 months after discharge,and the patients were divided into poor prognosis group and good prognosis group according to the follow-up results.Pearson correlation was used to analyze the correlation between serum HDAC3,TSG-6,FSTL1 levels and left ventricular ejection fraction(LVEF)in UAP patients.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in UAP patients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum HDAC3,TSG-6 and FSTL1 alone and their combination for poor prognosis in UAP patients.Results The serum levels of HDAC3 and TSG-6 in the observation group were higher than those in the control group,and the serum level of FSTL1 in the observation group was lower than that in the control group,and the differences were statistically significant(P＜0.05).There were 55 cases in low-risk group,40 cases in medium-risk group and 35 cases in high-risk group.The serum levels of HDAC3 and TSG-6 in the high-risk group and medium-risk group were higher than those in the low-risk group,and the serum levels of HDAC3 and TSG-6 in the high-risk group were higher than those in the medium-risk group,and the differences were statistically significant(P＜0.05).The serum levels of FSTL1 in the high-risk group and medium-risk group were lower than that in the low-risk group,and the serum level of FSTL1 in the high-risk group was lower than that in the medium-risk group,and the differences were statistically significant(P＜0.05).There were 47 cases in the poor prognosis group and 83 cases in the good prognosis group.The levels of serum HDAC3 and TSG-6 in the poor prognosis group were higher than those in the good prognosis group,and the levels of LVEF and serum FSTL1 in the poor prognosis group were lower than those in the good prog-nosis group,and the differences were statistically significant(P＜0.05).Pearson correlation analysis showed that serum HDAC3 and TSG-6 levels were negatively correlated with LVEF,and serum FSTL1 level was pos-itively correlated with LVEF in UAP patients(P＜0.05).Multivariate Logistic regression analysis showed that increased serum HDAC3 and TSG-6 levels were risk factors for poor prognosis in UAP patients(P＜0.05),and increased LVEF and serum FSTL1 levels were protective factors for poor prognosis in UAP pa-tients(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of serum HDAC3,TSG-6,FSTL1 alone and their combination for predicting poor prognosis of UAP patients were 0.853,0.833,0.755,0.932,respectively.The AUC of combined prediction was greater than that of individual prediction(Z=2.937,2.878,4.288,P＜0.05).Conclusion The serum levels of HDAC3 and TSG-6 in UAP patients are increased,and the level of FSTL1 is decreased,which are related to cardiac function.The combined detec-tion of the three indicators has a high predictive value for the poor prognosis of UAP patients.