血清HDAC3、sFasL对帕金森病患者发生认知功能障碍的预测价值OA

Objective To investigate the predictive value of serum histone deacetylase 3(HDAC3)and sol-uble apoptosis factor ligand(sFasL)for cognitive impairment(CI)in patients with Parkinson's disease(PD).Methods A total of 154 PD patients admitted to the hospital from October 2022 to February 2025 were se-lected as the PD group.Another 154 healthy people who underwent physical examination in the hospital dur-ing the same period were selected as the control group.Baseline data of all subjects were collected.The levels of HDAC3,sFasL,interleukin(IL)-6 and tumor necrosis factor-α(TNF-α)in serum of all subjects were de-tected by enzyme-linked immunosorbent assay.According to the Montreal Cognitive Assessment(MoCA)score,PD patients were divided into normal cognitive function group and CI group.Pearson/Spearman correla-tion analysis was used to analyze the correlation of serum HDAC3 and sFasL levels with Hoehn Yahr(H-Y)stage,Unified Parkinson's Disease Rating Scale(UPDRS)score,MoCA score,IL-6 and TNF-α levels in PD patients.Multivariate Logistic regression was used to analyze the influencing factors of CI in PD patients.Re-ceiver operator characteristic(ROC)curve was drawn to analyze the predictive value of serum HDAC3,sFasL alone and their combination for CI in PD patients.Results The UPDRS score and MoCA score of the PD group were lower than those of the control group,and the serum levels of HDAC3,sFasL,IL-6 and TNF-α were higher than those of the control group,and the differences were statistically significant(P＜0.05).There were 51 cases in CI group and 103 cases in normal cognitive function group.Compared with the normal cognitive function group,the CI group had significantly higher proportion of patients with moderate to late H-Y stage and serum levels of HDAC3,sFasL,IL-6 and TNF-α(P＜0.05),and significantly lower UPDRS score and MoCA score(P＜0.05).Pearson/Spearman correlation analysis showed that serum HDAC3 level was positively correlated with sFasL level in PD patients(P＜0.05).The serum levels of HDAC3 and sFasL were negatively correlated with UPDRS score and MoCA score(P＜0.05),and positively correlated with H-Y stage,IL-6 and TNF-α levels(P＜0.05).Multivariate Logistic regression analysis showed that advanced H-Y stage,increased IL-6,TNF-α,HDAC3 and sFasL levels were risk factors for CI in PD patients(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum HDAC3,sFasL alone and their combination for predicting CI in PD patients were 0.761,0.785 and 0.848,respectively.The AUC of com-bined prediction was greater than serum HDAC3,sFasL single prediction(Z=2.519,2.543,P＜0.05).Con-clusion The serum levels of HDAC3 and sFasL in PD patients are abnormally increased,and both of them are related to the occurrence of CI.The combined detection of serum levels of HDAC3 and sFasL has certain pre-dictive value for CI in PD patients.