硫黄菌活性成分及其药理作用研究进展OA

Laetiporus sulphureus is an edible and medicinal macrofungus widely distributed in temperate regions,typically parasitizing broadleaf trees and possessing significant nutritional,economic,and ecological value.In recent years,with the growing interest in natural products and functional foods,this fungus has attracted considerable attention due to its diverse chemical constituents and notable biological activities.Studies have shown that its fruiting bodies and mycelia are rich in various bioactive compounds,including polysaccharides,triterpenoids,sterols,sesquiterpenes,and polyphenols.These constituents exhibit a wide range of pharmacological activities,such as antitumor,anti-inflammatory,antioxidant,immunomodulatory,and metabolic regulatory effects.This review systematically summarizes the major classes and structural characteristics of these chemical constituents from L.sulphureus.Particular emphasis is placed on their pharmacological activities,especially antitumor and anti-inflammatory effects,along with the underlying molecular mechanisms,including the regulation of oxidative stress,inflammatory signaling pathways,and apoptosis.In addition,current limitations,such as insufficient studies on active substances,unclear mechanisms of action,and lack of clinical evidence,are critically discussed.Finally,future perspectives on the application of L.sulphureus in drug discovery and functional food development are proposed,aiming at providing a theoretical basis for its further research and high-value utilization.