乳腺癌超声造影定量参数与Wnt/β-catenin信号通路蛋白表达的关联研究OA

Objective To investigate the correlation between quantitative parameters of contrast-enhanced ultrasound(CEUS)and Wnt/β-catenin signaling pathway protein expression in breast cancer,so as to provide a molecular basis for noninvasive assessment.Methods A retrospective case-control study was conducted.A total of 100 patients with breast cancer were enrolled as case group,and 100 patients with benign breast masses during the same period were enrolled as control group,matched 1∶1 by age and body mass index.CEUS was performed in both groups,and parame-ters including time to peak(TTP),peak intensity(PI),and area under the curve(AUC)were measured.The relative expression levels of β-catenin,c-Myc,and Cyclin D1 proteins in breast tissue were determined by Western blot.Pearson correlation analysis was used to evaluate the correlation be-tween CEUS quantitative parameters and the expression of β-catenin,c-Myc,and Cyclin D1 pro-teins.Results The proportions of hyperenhancement,fast-in and slow-out enhancement pattern,and centripetal contrast agent entry,as well as PI and AUC,were higher in the case group than those in the control group,while TTP was shorter in the case group than that in the control group(P＜0.05).The relative expression levels of β-catenin,c-Myc,and Cyclin D1 proteins were higher in the case group than in the control group(P＜0.05).Pearson correlation analysis showed that TTP was nega-tively correlated with the expression of β-catenin,c-Myc,and Cyclin D1 proteins,whereas PI and AUC were positively correlated with the expression of these proteins(P＜0.05).Conclusion CEUS quantitative parameters TTP,PI,and AUC are closely correlated with β-catenin,c-Myc,and Cyc-lin D1 proteins in breast cancer,which facilitates comprehensive assessment of the malignant biolog-ical behavior of breast cancer and provides new insights for the formulation of individualized treat-ment strategies.