基于"亢害承制"理论探讨巨噬细胞极化在慢性阻塞性肺疾病中的作用及治疗OA

Chronic obstructive pulmonary disease(COPD)is a common respiratory disease in clinical practice,featuring a complex pathogenesis.An imbalance in M1/M2 macrophage polarization plays a significant role in the pathogenesis of COPD,contributing to pathological processes such as inflammatory injury,oxidative stress,and airway remodeling.This study innovatively tries to elucidate on this disease based on the theory of"restraining excessiveness to acquire harmony",proposing that the disharmony caused by deficiency of the lung,spleen and kidney,and the damage induced by excessive phlegm-turbidity and blood stasis,share isomorphism with the imbalance in macrophage polarization.It is suggested that TCM targeted interventions be employed to regulate the dynamic balance of M1/M2 macrophage polarization,aiming to maintain bodily homeostasis and achieve a significant effect for COPD.