基于"虚损瘀毒"理论与肠道菌群相关性探讨阿尔茨海默病的防治OA

Alzheimer's disease(AD),a neurodegenerative disorder,is characterized by a complex pathogenesis and a lack of effective treatment.This study explores strategies for the prevention and treatment of AD based on the traditional Chinese medicine(TCM)theory of"deficiency,stasis and toxin",combined with the modern research on gut microbiome omics.It is found that spleen and kidney deficiency constitutes the root cause of AD,while phlegm,stasis,turbidity,and toxins obstructing the cerebral meridians represents its manifestations,and the two factors form a vicious cycle of"deficiency-stasis-toxin".Dysbiosis of the gut microbiota is closely associated with the pathological progression of AD by disrupting the gut-brain axis homeostasis,thereby exacerbating neuroinflammation and metabolic disorders.TCM interventions(such as Danggui Shaoyao San and tonifying formulas)may significantly improve the cognitive function in AD animal models by regulating the gut microbiota composition,repairing the intestinal mucosal barrier,and inhibiting the release of inflammatory factors.This study is aimed at providing a theoretical basis for the integrated prevention and treatment of AD using both western and traditional Chinese medicine,revealing the scientific rationale behind TCM's multi-target regulation via the"gut-brain axis",and opening new pathways for the precision treatment of AD.