高温对高尿酸血症患者勃起功能障碍影响的研究现状、热点述评与展望OA

Hyperuricemia(HUA)is one of the risk factors for erectile dysfunction(ED).By inducing vascular endothelial dysfunction,insulin resistance and other pathological processes,HUA forms a complex pathological network interwoven via the crosstalk among multiple pathways,which synergistically drives the onset and progression of ED.Existing evidence indicates that high ambient temperature can not only elevate serum uric acid levels,but also synergistically aggravate the risk of ED in HUA patients by activating pathways including the inflammasome pathway,the polyol-fructokinase pathway and the oxidative stress pathway.In this review,we summarize the epidemiological association and underlying pathological mechanisms between HUA and ED,focusing on the accelerator effect of high ambient temperature in the causal link between HUA and ED,and propose the novel hypothesis of"heat-HUA-ED"triad.Further studies are required to validate this hypothesis in animal models and explore targeted intervention strategies for these common pathways,such as nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome,so as to provide novel insights from the cross-disciplinary field of environmental and metabolic research for the prevention and treatment of HUA complicated with ED.