运用子午流注理论防治糖尿病血糖波动OA
Prevention and Treatment of Blood-Glucose Fluctuation in Diabetes Mellitus Based on the Midnight-Noon Ebb-Flow Theory
子午流注理论认为,经脉气血处于"旺时",脏腑精气最盛,功能最强;若气血不足或运行不畅,气血未至而脏腑失去滋养,容易导致功能失调,即为"气血未至而脏腑过劳",这一机制恰能解释糖尿病血糖波动现象.消渴患者脏腑功能失调,若叠加昼夜节律紊乱,气血流注失序,则会导致气血未至,脏腑"旺时"气血灌注不足,水谷精微输布失常,停滞于脉道,血糖升高;气血迟滞,脏腑失养、功能减退,血糖利用障碍,出现异常低血糖;气滞血瘀,精微物质输布受阻,血糖居高不下或波动不稳.预防血糖波动需要注重恢复人体自身节律和整体稳态,做到规律作息,顺应自然节律.子午流注理论中"择时"是关键,其优势在于基于时间维度形成个体化干预治疗方案,该方案通过择时给药、外治法、饮食管理和择时运动等多种方式进行干预,与现代医学糖尿病综合管理的"五驾马车"理念形成互补,从而达到协同稳定血糖波动的目标.
According to the midnightnoon ebbflow theory,when qiblood in the meridians reaches its peak period,the zang-fu essenceqi is the most abundant and visceral functions are at their strongest.Insufficient qiblood or impeded circulation may deprive zang-fu organs of nourishment prior to the arrival of qiblood,thereby triggering visceral dysfunction,a pathological condition defined as"overstrain of zang-fu organs before qiblood arrives".This mechanism can well explain the phenomenon of bloodglucose fluctuation in diabetes melli-tus.Patients with diabetesthirst disorder suffer from visceral dysfunction.When complicated with circadian rhythm disturbance and disor-dered qiblood flow,qiblood fails to arrive on time,leading to inadequate perfusion of qiblood during the peakactivity phase of zang-fu or-gans.Subsequently,the transportation and distribution of food essence are disturbed,and nutrients stagnate within vessels,resulting in elevated blood glucose.Delayed circulation of qiblood deprives zang-fu organs of nourishment and impairs their functions,hindering glu-cose utilization and consequently causing pathological hypoglycemia.Qistagnation and bloodstasis block the transportation and distribu-tion of nutrient essence,giving rise to persistently high blood glucose or unstable glycemic fluctuation.Preventing bloodglucose fluctua-tion needs to focus on restoring endogenous human circadian rhythm and holistic homeostasis via regular daily routines conforming to natural rhythms.According to the theory of midnight-noon ebb-flow,time-selection constitutes the core.Its advantage lies in developing individualized intervention regimens from the temporal dimension.Such regimens are implemented through multiple modalities including time-phased medication administration,external therapies,dietary regulation and timed physical exercise.They can complement the"fivecarriage"strategy of comprehensive diabetes management in modern medicine,so as to jointly stabilize bloodglucose fluctuation.
杨晶洁;刘添娇;徐菁晗;张琦;朴春丽
广州中医药大学深圳医院(福田),广东 深圳 518000广州中医药大学深圳医院(福田),广东 深圳 518000广州中医药大学深圳医院(福田),广东 深圳 518000广州中医药大学深圳医院(福田),广东 深圳 518000广州中医药大学深圳医院(福田),广东 深圳 518000
医药卫生
糖尿病血糖波动子午流注理论时间医学
diabetes mellitusbloodglucose fluctuationmidnightnoon ebbflow theorytime medicine
《河南中医》 2026 (9)
1354-1358,5
国家自然科学基金项目(82374280)广东省基础与应用基础研究基金项目(2023A1515220236)深圳市"医疗卫生三名工程"项目(SZZYSM202202010)深圳市科技计划项目(JCYJ20220531091409022,JCYJ20240813160612016)
评论