黄芪建中汤对脾胃虚寒型幽门螺杆菌感染相关性胃炎患儿胃肠功能和免疫功能的影响OA
The Effect of Astragalus Center-Fortifying Decoction on Gastrointestinal Function and Immune Function in Children with Helicobacter pylori-Associated Gastritis of Spleen-Stomach Deficiency-Cold Type
目的:观察黄芪建中汤对脾胃虚寒型幽门螺杆菌(helicobacter pylori,Hp)感染相关性胃炎患儿胃肠功能和免疫功能的影响.方法:选取2024 年9 月至2025 年1 月南阳市中心医院诊治的脾胃虚寒型 Hp 相关性胃炎患儿110 例,按照随机单双数法分为对照组和中药组,每组各55 例.对照组给予常规三联疗法治疗,中药组在对照组治疗的基础上加用黄芪建中汤治疗.观察两组患儿不良反应发生情况及治疗前后中医证候积分、胃肠功能[P 物质(substance P,SP)、胃动素(motilin,MLT)和胃泌素(gastrin,GAS)]、炎性因子[超敏 C 反应蛋白(hs-C reactive protein,hs-CRP)、肿瘤坏死因子(tumor necrosis factor,TNF)-α、白细胞介素(interleukin,IL)-8 和 IL-6]、免疫功能变化情况.结果:中药组治疗后食少便溏、四肢不温、神疲肢乏、喜暖喜按、胃脘隐痛等中医证候积分低于对照组,差异具有统计学意义(P<0.05);中药组治疗后 SP、GAS 水平低于对照组,MLT 水平高于对照组,差异具有统计学意义(P<0.05);中药组治疗后 hs-CRP、TNF-α、IL-8、IL-6 水平低于对照组,差异具有统计学意义(P<0.05);中药组治疗后 CD8+低于对照组,免疫球蛋白(immunoglobulin,Ig)A、CD4+/CD8+、IgM、IgG 高于对照组,差异具有统计学意义(P<0.05);中药组不良反应发生率为3.64％,对照组不良反应发生率为5.45％,两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:黄芪建中汤能够有效缓解脾胃虚寒型 Hp 相关性胃炎患儿炎症反应,还可调节其免疫功能和胃肠功能,改善中医证候.
Objective:To observe the effect of Astragalus Center-Fortifying Decoction on gastrointestinal function and immune function in children with Helicobacter pylori(Hp)-associated gastritis of spleen-stomach deficiency cold type.Methods:A total of 110 children with Hp-associated gastritis of spleen-stomach deficiency-cold type diagnosed and treated at Nanyang Central Hospital from September 2024 to January 2025 were selected and divided into the control group and the Chinese medicinal group using the random odd-even number method,with 55 cases in each group.The control group received conventional triple therapy,while the Chinese medicinal group received Astragalus Center-Fortifying Decoction in addition to the treatment given to the control group.Then TCM syndrome scores,gastrointesti-nal function[substance P(SP),motilin(MLT),and gastrin(GAS)],inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF)-α,interleukin(IL)-8,and IL-6],immune function,and adverse reactions were observed in the two groups.Results:After treatment,the TCM syndrome scores for poor appetite with loose stools,cold limbs,fatigue and weakness,prefer-ence for warmth and pressure,and dull epigastric pain in the Chinese medicinal group were lower than those in the control group,with statistically significant differences(P<0.05).SP and GAS levels in the Chinese medicinal group were lower than those in the control group,while MLT level was higher than that in the control group,with statistically significant differences(P<0.05).The levels of hs-CRP,TNF-α,IL-8,and IL-6 in the Chinese medicinal group were lower than those in the control group,with statistically significant differences(P<0.05).The CD8+level in the Chinese medicinal group was lower than that in the control group,while the levels of im-munoglobulin(Ig)A,CD4+/CD8+,IgM,and IgG were higher than those in the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions was3.64％in the Chinese medicinal group and5.45％in the control group,but there was no statistically significant difference between the two groups(P>0.05).Conclusion:Astragalus Center-Fortifying Decoction can ef-fectively alleviate the inflammatory response in children with Hp-associated gastritis of spleen-stomach deficiency-cold type,regulate their immune function and gastrointestinal function,and improve TCM syndromes.
陈志鑫;范暖东;宋莉;张伟东;陈白璐;王啸尘
南阳市中心医院,河南 南阳 473000南阳市中心医院,河南 南阳 473000南阳市中心医院,河南 南阳 473000南阳市中心医院,河南 南阳 473000南阳市中心医院,河南 南阳 473000南阳市中心医院,河南 南阳 473000
医药卫生
幽门螺杆菌感染相关性胃炎黄芪建中汤脾胃虚寒证胃肠功能免疫功能《金匮要略》张仲景
Helicobacter pylori(Hp)-associated gastritisAstragalus Center-Fortifying Decoctionspleen-stomach deficiency-cold syn-dromegastrointestinal functionimmune functionSynopsis of the Golden ChamberZhang Zhongjing
《河南中医》 2026 (9)
1325-1329,5
河南省医学科技攻关计划联合共建项目(LHGJ20202015)南阳市科技计划项目(24KGG168)
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