阶段性言语康复与音乐治疗卒中后失语症临床研究OA

Objective To analyze the efficacy of stage speech rehabilitation and music therapy for aphasia after stroke.Methods A total of 93 patients with post-stroke aphasia admitted to the Department of Neurology,the First Affiliated Hospital of Air Force Military Medical University from January 2022 to December 2024 were selected and divided into a speech training group(n=31),a music group(n=31),and a combined group(n=31)by the random number table method.The speech training group received staged speech rehabilitation training,and the music group received music therapy.The combined group was treated by staged speech rehabilitation combined with music therapy.The three groups were intervened for 3 months.The intervention effects of the three groups were evaluated.Before and after the intervention,the degree of aphasia(ABC score),psychological resilience(CD-RISC score)and vocal function of the patients were assessed.The levels of serum calcitonin gene-related peptide(CGRP),brain-derived neurotrophic factor(BDNF),and endothelin-1(ET-1)were detected.Results The effective rate of the combined group was 96.77%(30/31),which was higher than 77.42%(24/31)in the speech training group and 74.19%(23/31)in the music group(P<0.05).After intervention,the scores of ABC and CD-RISC in the three groups increased(P<0.05),and the combined group was higher than the speech training group and the music group(P<0.05).After intervention,the levels of CGRP and BDNF in the three groups increased,and the combined group was higher than the speech training group and the music group(P<0.05).The levels of ET-1 in the three groups decreased,and the combined group was lower than the speech training group and the music group(P<0.05).After intervention,the longest vocalization time of the three groups was prolonged(P<0.05),but there was no significant difference among the three groups(P>0.05).There were no significant differences in volume,tone and average vocal air flow among the three groups before and after treatment(P>0.05).Conclusion Staged speech rehabilitation combined with music therapy can significantly improve the vocal function and aphasia degree of patients with post-stroke aphasia,enhance their psychological resilience,and help to improve cerebral blood flow,protect cranial nerves,promote neural function reconstruction,and alleviates ischemic injury.