血清DFR与FAR对急性缺血性脑卒中相关性肺炎的预测价值OA

Objective To analyze the predictive value of D-dimer to fibrinogen ratio(DFR)and fibrinogen to albumin ratio(FAR)for stroke associated pneumonia(SAP)associated with acute ischemic stroke(AIS).Methods Totally 200 AIS patients admitted to the Neurology Department of Xinxiang Central Hospital from January 2023 to January 2024 were selected as the research subjects.Based on whether they developed SAP during the hospitalization,they were divided into SAP group(62 cases)and non-SAP group(138 cases).A systematic screening of potential risk factors was conducted using multivariate Logistic regression analysis to identify independent predictive factors for SAP.The odds ratio(ORs)and 95%confidence interval(CI)for each factor were calculated.The receiver operating characteristic(ROC)curve was plotted,and the area under curve(AUC)was calculated to determine the optimal diagnostic threshold.Additionally,the corresponding sensitivity and specificity were calculated.Results The median age of patients in the SAP group(70.00 years old)was significantly higher than that of the non-SAP group(51.50 years old).The proportion of patients with complications such as swallowing dysfunction and atrial fibrillation was significantly increased,and their NIHSS scores upon admission were higher(P<0.01).Additionally,their levels of D-dimer,DFR,and FAR were elevated(P<0.01).The serum albumin levels of patients in the SAP group were significantly lower than those in the non-SAP group(P<0.01).Logistic regression analysis revealed that atrial fibrillation,swallowing dysfunction,NIHSS score upon admission,DFR,and FAR levels were independent risk factors for the development of SAP in AIS patients(P<0.05).ROC curve analysis indicated that the AUC of serum DFR was 0.863(95%CI:0.783-0.933),with a sensitivity of 82.3%and a specificity of 94.9%.The AUC of serum FAR was 0.794(95%CI:0.709-0.868),with a sensitivity of 64.5%and a specificity of 92.8%.Conclusion Atrial fibrillation,dysphagia,elevated NIHSS scores,DFR and FAR levels are independent risk factors for SAP in AIS patients.Elevated serum DFR and FAR levels have early clinical predictive value for the development of SAP in AIS patients.