黄芪泽苓颗粒联合特利加压素治疗顽固性腹水疗效及对患者免疫相关因子的影响OA
Efficacy of Huangqi Zeling granules combined with terlipressin in the treatment of refractory ascites and its effects on immune-related factors
目的 观察黄芪泽苓颗粒联合特利加压素治疗顽固性腹水的临床疗效及对免疫相关因子、腹水深度的影响.方法 选取2021 年1 月至2023 年12 月西安长安医院消化内科收治的96 例顽固性腹水患者作为研究对象,采用随机数字表法分为治疗组(n=48,脱落 2 例)和对照组(n=48,脱落 3 例).对照组予特利加压素治疗,治疗组在对照组基础上加黄芪泽苓颗粒治疗.统计 2 组临床疗效、不良反应及腹水深度、腹围、24 h 尿量、免疫相关因子[白细胞介素 8(IL-8)、细胞间黏附分子 1(ICAM-1)]、肝功能指标[天冬氨酸氨基转移酶(AST)、总胆红素(TBil)、白蛋白(Alb)]水平.结果 治疗组总有效率为 89.13%(41/46),对照组总有效率为 68.89%(31/45),治疗组总有效率高于对照组(P<0.05).治疗 1、2 个月,2 组腹水深度、腹围、血清和腹水 IL-8、ICAM-1 水平、血清 AST、TBil 水平均低于治疗前(P<0.05),且治疗组均低于对照组同期(P<0.05).治疗 1、2 个月,2 组24 h 尿量和血清 Alb 水平均高于治疗前(P<0.05),且治疗组均高于对照组同期(P<0.05).治疗组不良反应总发生率为 8.70%(4/46),对照组为 13.33%(6/45),2 组不良反应总发生率比较差异无统计学意义(P>0.05).结论 黄芪泽苓颗粒联合特利加压素治疗顽固性腹水疗效确切,可有效缓解腹水症状,提高 24 h 尿量,促进肝功能恢复,且具有一定安全性,其机制可能与调节免疫相关因子有关.
Objective To observe the clinical efficacy of Huangqi Zeling granules combined with terlipressin in the treatment of refractory ascites and to evaluate its effects on immune-related factors and ascites depth.Methods A total of 96 patients with refractory ascites admitted to the Department of Gastroenterology of Chang'an Hospital from January 2021 to December 2023 were enrolled and randomly assigned to a treatment group(n=48,2 dropouts)and a control group(n=48,3 dropouts)using a random number table.The control group received terlipressin,while the treatment group received Huangqi Zeling granules in addition to terlipressin.Clinical efficacy,adverse reactions,ascites depth,abdominal circumference,24 h urine volume,immune-related factors(interleukin-8[IL-8],intercellular adhesion molecule-1[ICAM-1]),and liver function indicators(aspartate aminotransferase[AST],total bilirubin[TBil],and albumin[Alb])were recorded and compared between the two groups.Results The treatment group had a significantly higher total effective rate than the control group(89.13%[41/46]vs 68.89%[31/45],P<0.05).After 1 and 2 months of treatment,ascites depth,abdominal circumference,serum and ascitic fluid IL-8 and ICAM-1 levels,as well as serum AST and TBil levels,were lower than baseline in both groups(P<0.05),and were lower in the treatment group than in the control group at the same time points(P<0.05).After 1 and 2 months of treatment,24 h urine volume and serum Alb levels were higher than baseline in both groups(P<0.05),and were higher in the treatment group than in the control group at the same time points(P<0.05).The overall incidence of adverse reactions was 8.70%(4/46)in the treatment group and 13.33%(6/45)in the control group;there was no statistically significant difference between the two groups(P>0.05).Conclusion Huangqi Zeling granules combined with terlipressin is effective in treating refractory ascites.It can alleviate ascites-related symptoms,increase 24 h urine volume,promote recovery of liver function,and appears to be safe.Its mechanism may be related to the regulation of immune-related factors.
师杰;李文忠;周毅;周清文
西安长安医院消化内科,陕西 西安 710016西安长安医院消化内科,陕西 西安 710016西安长安医院消化内科,陕西 西安 710016西安长安医院消化内科,陕西 西安 710016
医药卫生
腹水肝硬化中医药疗法特利加压素白细胞介素8细胞间黏附分子-1
AscitesLiver cirrhosisTraditional Chinese medicine therapyTerlipressinInterleukin-8Intercellular adhesion molecule-1
《河北中医》 2026 (9)
1459-1463,1468,6
陕西省重点研发计划项目(编号:2021SF-031)
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