益气养阴通络汤联合针刺对围绝经期骨质疏松症脂肪细胞因子、骨硬化蛋白及血清钙磷乘积、谷胱甘肽过氧化物酶4的影响OA
Effects of Yiqi Yangyin Tongluo Decoction combined with acupuncture on adipocytokines,sclerostin,serum calcium-phosphorus product,and glutathione peroxidase 4 in perimenopausal osteoporosis
目的 观察益气养阴通络汤联合针刺对围绝经期骨质疏松症患者脂肪细胞因子、骨硬化蛋白及血清钙磷乘积、谷胱甘肽过氧化物酶 4(GPX4)的影响.方法 选择 2021 年 5 月至 2023 年 10 月梧州市中医医院围绝经期骨质疏松症患者 102 例,采用随机数字表法分为 2 组.对照组 51 例进行常规西医治疗,治疗组 51 例在对照组基础上加益气养阴通络汤联合针刺治疗.比较 2 组临床疗效、中医证候评分、六点行为评分法(BRS-6)评分、骨密度值、中国人骨质疏松症简明生存质量量表(COQOL)评分及骨硬化蛋白、晚期糖基化终末产物(AGEs)、肿瘤坏死因子 α(TNF-α)、GPX4、脂联素、瘦素、核因子 кB 受体活化因子配基(RANKL)、雌二醇、卵泡刺激素、钙磷乘积水平.结果 治疗组临床疗效优于对照组,比较差异有统计学意义(P<0.05).治疗后,2 组各项中医证候、BRS-6、COQOL 评分及 AGEs、TNF-α、脂联素、瘦素、卵泡刺激素、骨硬化蛋白、RANKL 水平均较本组治疗前降低(P<0.05),且治疗组均低于对照组(P<0.05).治疗后,2组骨密度值、GPX4、雌二醇、钙磷乘积均较本组治疗前升高(P<0.05),且治疗组均高于对照组(P<0.05).结论 益气养阴通络汤联合针刺治疗围绝经期骨质疏松症患者,可调节脂肪细胞因子、钙磷乘积水平,减轻炎症及氧化应激损伤,改善骨代谢及性激素水平,缓解病情,提升骨密度及临床疗效.
Objective To observe the effects of Yiqi Yangyin Tongluo Decoction combined with acupuncture on adipocytokines,sclerostin,serum calcium-phosphorus product,and glutathione peroxidase 4(GPX4)in patients with perimenopausal osteoporosis.Methods A total of 102 patients with perimenopausal osteoporosis treated at Wuzhou Hospital of Traditional Chinese Medicine from May 2021 to October 2023 were enrolled and randomly assigned to two groups using a random number table.The control group included 51 patients who received conventional Western medical treatment,while the treatment group included 51 patients who received Yiqi Yangyin Tongluo Decoction combined with acupuncture in addition to the treatment given to the control group.Clinical efficacy,traditional Chinese medicine syndrome scores,six-point behavioral rating scale(BRS-6)scores,bone mineral density,Chinese Osteoporosis Quality of Life Questionnaire(COQOL)scores,and the levels of sclerostin,advanced glycation end products(AGEs),tumor necrosis factor-α(TNF-α),GPX4,adiponectin,leptin,receptor activator of nuclear factor κB ligand(RANKL),estradiol,follicle-stimulating hormone,and the calcium-phosphorus product were compared between the two groups.Results The clinical efficacy in the treatment group was superior to that in the control group,with a statistically significant difference(P<0.05).After treatment,,traditional Chinese medicine syndrome scores,BRS-6 and COQOL scores,as well as the levels of AGEs,TNF-α,adiponectin,leptin,follicle-stimulating hormone,sclerostin,and RANKL,decreased in both groups compared with baseline(P<0.05),and were lower in the treatment group than in the control group(P<0.05).After treatment,bone mineral density,GPX4,estradiol,and the calcium-phosphorus product increased in both groups compared with baseline(P<0.05),and were higher in the treatment group than in the control group(P<0.05).Conclusion Yiqi Yangyin Tongluo Decoction combined with acupuncture can regulate adipocytokines and the calcium-phosphorus product,reduce inflammatory and oxidative stress injury,improve bone metabolism and sex hormone levels,alleviate disease severity,and enhance bone mineral density and clinical efficacy in patients with perimenopausal osteoporosis.
彭跃文;蔡云聪;肖贻月
广西壮族自治区梧州市中医医院治未病科,广西 梧州 543000广西壮族自治区梧州市中医医院治未病科,广西 梧州 543000广西壮族自治区梧州市中医医院治未病科,广西 梧州 543000
医药卫生
骨质疏松,绝经后中医药疗法益气养阴通络汤针刺疗法钙磷乘积谷胱甘肽过氧化物酶4
Perimenopausal osteoporosisTraditional Chinese medicine therapyYiqi Yangyin Tongluo DecoctionAcupuncture therapyCalcium-phosphorus productGlutathione peroxidase 4
《河北中医》 2026 (9)
1426-1430,5
广西壮族自治区中医药管理局自筹经费科研课题(编号:GZGC2022880)
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