西北燥证患者冠心病发病情况及其与心血管事件风险的相关性OA

Objective To investigate the incidence of coronary atherosclerotic heart disease(CAD,coronary heart disease for short)in patients with northwest dryness syndrome,and analyze the correlation between northwest dryness syndrome and the risk of major adverse cardiovascular events(MACE)in CAD patients.Methods Three hundred and fifty patients first diagnosed with northwest dryness syndrome at the Second Affiliated Hospital of Xinjiang Medical University,from January 2021 to December 2023 were selected as the dryness syndrome group,and 350 patients without northwest dryness syndrome who visited the same hospital during the same period were selected as the control group.General data,laboratory examination data and imaging data were collected.After propensity score matching(PSM)based on general data,the difference in the proportion of CAD between the two groups was statistically analyzed.Then all CAD patients were followed up for 1 year,and the occurrence of MACE during follow-up was recorded.All patients were grouped according to the follow-up results,and the correlation between northwest dryness syndrome and the risk of MACE in CAD patients under the influence of different covariates was analyzed by Cox regression.Results(1)Before matching,there were significant differences in age,body mass index(BMI),hypertension and smoking history between the dryness syndrome group and the control group(P＜0.05 or P＜0.01).After PSM,262 pairs of patients were successfully matched.The covariates were balanced between the two groups after matching,and the balance of PSM covariates was significantly improved.There were no statistically significant differences in gender,age,BMI,underlying diseases,smoking history and drinking history between the two groups(P＞0.05).The incidence of CAD was 66.41%(174/262)in the dryness syndrome group and 57.25%(150/262)in the control group.The incidence of CAD in the dryness syndrome group was significantly higher than that in the control group(χ2=4.658,P=0.031).(2)By the end of follow-up on December 31,2024,a total of 304 CAD patients were included in this study,with a median follow-up time of(13.51±2.09)months.During follow-up,64 patients met the MACE criteria,so the final grouping was MACE group(64 cases)and non-MACE group(240 cases).The proportions of northwest dryness syndrome and hyperlipidemia in the MACE group were higher than those in the non-MACE group,with statistically significant differences(P＜0.05 or P＜0.01).The levels of triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),average stenosis degree and the proportion of multi-vessel disease in the MACE group were significantly higher than those in the non-MACE group,with statistically significant differences(P＜0.01).(3)Cox regression analysis showed that northwest dryness syndrome,elevated TG,elevated LDL-C,larger average stenosis degree and number of diseased vessels were all independent related factors affecting MACE occurrence in CAD patients.Among them,compared with multi-vessel disease,single-vessel disease and double-vessel disease were independent protective factors(P＜0.05 or P＜0.01).Conclusion Patients with northwest dryness syndrome have a higher incidence of CAD,and northwest dryness syndrome is an independent risk factor for MACE in CAD patients,which should be paid attention to in clinical practice.