特发性膜性肾病患者不同危险分层证候要素分布规律OA

Objective To explore the distribution patterns of traditional Chinese medicine(TCM)symptoms and syndrome elements in patients with idiopathic membranous nephropathy(IMN),so as to provide clinical evidence for TCM syndrome differentiation and treatment of IMN.Methods Clinical data of 100 patients with IMN as the primary diagnosis who were treated in the outpatient and inpatient departments of Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from May 2024 to May 2025 were prospectively collected for TCM syndrome element determination.Descriptive statistics and correlation analysis were used to explore the distribution characteristics of TCM symptoms and syndrome elements in IMN patients and their correlations with gender,age and 24-hour urinary total protein(24hUTP).Results Among 100 IMN patients,common symptoms included frothy urine(94.00%),fatigue(76.00%),edema(75.00%),lower back soreness(68.00%)and forgetfulness(60.00%).The main location syndrome elements were kidney(90.00%),spleen(67.00%)and liver(57.00%).The main nature syndrome elements were qi deficiency(77.00%),water retention(76.00%),dampness(64.00%),yin deficiency(62.00%),blood deficiency(62.00%),heat(55.00%)and blood stasis(46.00%).Correlation analysis showed that in terms of gender difference,the proportion of yang hyperactivity syndrome element in female patients was higher than that in male patients(P＜0.01).In terms of age,the proportion of blood deficiency syndrome element showed an increasing trend with age(P＜0.05).In addition,with the increase of proteinuria,the proportions of water retention,dampness,heat,blood stasis,phlegm and wind syndrome elements all showed increasing trends(P＜0.05 or P＜0.01),among which the severity of water retention syndrome,heat syndrome and blood stasis syndrome also showed increasing trends(P＜0.05 or P＜0.01).Conclusion IMN is a disease of intermingled deficiency and excess mainly characterized by qi deficiency,yin deficiency,blood deficiency,water retention,dampness,heat and blood stasis,with the main disease locations in the kidney,spleen and liver.The distribution of its syndrome elements has certain correlations with gender,age and degree of proteinuria.