生境成像对早期肺腺癌侵袭性预测的研究进展OA

Lung adenocarcinoma(LUAD)exhibits marked biological and spatial heterogeneity.Accurate preoperative assessment of pathological invasiveness in early-stage LUAD,including high-grade components,lymph node metastasis,and microscopic invasive features,is critical for individualized surgical and adjuvant treatment planning.Habitat imaging decomposes tumors into spatial subregions with distinct biological characteristics,thereby enabling quantitative assessment of intratumoral heterogeneity.This technique has shown advantages in predicting high-grade histological subtypes,assessing lymph node metastasis status,and identifying microscopic invasive behaviors such as lymphovascular invasion,visceral pleural invasion,and spread through air spaces in early-stage LUAD.This review summarizes recent advances in habitat imaging for assessing invasiveness in early-stage LUAD.