低剂量与常规剂量CT提取肺磨玻璃结节影像组学特征的可重复性分析OA

Objective To analyze the reproducibility of radiomic features extracted from pulmonary ground-glass nodules(GGNs)on low-dose and conventional-dose CT.Methods A total of 292 patients who underwent low-dose CT screening for pulmonary nodules and additional conventional-dose CT scanning of the GGN region were retrospectively included.In total,306 GGNs with a maximum diameter of 5-30 mm were included.Two physicians manually segmented GGNs on both types of CT images,and 107 radiomic features(shape features,first-order features,and texture features)were extracted.The intraclass correlation coefficient(ICC)was used to evaluate interobserver agreement in radiomic feature extraction.The radiation doses[volume CT dose index(CTDIvol),dose-length product(DLP),and effective dose(ED)]were compared between the two scanning protocols using the paired t-test.The concordance correlation coefficient(CCC)was used to evaluate the reproducibility of radiomic features extracted by the two scanning protocols.Results The interobserver and intraobserver agreement for radiomic feature extraction was high(all ICC>0.96).The CTDIvol,DLP,and ED were lower with low-dose CT than with conventional-dose CT(all P<0.05).Of the 107 radiomic features,48(44.9%)showed good reproducibility(CCC≥0.85),whereas 59(55.1%)showed poor reproducibility(CCC<0.85).First-order features had the highest CCC(0.90±0.08),with 77.8%(14/18)showing good reproducibility,while shape and texture features had lower CCCs(0.79±0.24 and 0.79±0.14,respectively),and 65.3%(49/75)of texture features showed poor reproducibility.Conclusion Among the GGN radiomic features extracted from low-dose and conventional-dose CT,first-order features showed good reproducibility,whereas texture features showed poor reproducibility;features with good reproducibility should be preferentially selected for low-dose CT radiomics analysis.