全自动固相萃取-超高效液相色谱-串联质谱法同时测定生活饮用水与地表水中11种新烟碱类农药OA

An analytical method was developed for the determination of 11 neonicotinoid pesticides in drinking water and surface water by automatic solid-phase extraction combined with ultra perfor-mance liquid chromatography-tandem mass spectrometry.The samples were purified and concentrated using an HLB solid-phase extraction column,separated on an AccucoreTM aQ C18 column(2.1 mm × 100 mm,2.6 μm),and then detected using positive-ion electrospray ionization coupled with multi-ple reaction monitoring mode.Quantification was achieved using internal standard calibration.The results showed that 11 neonicotinoid pesticides exhibited excellent linearity,with all correlation coef-ficients(r)above 0.999 5.The detection limits of the method were 0.015 0-1.50 ng/L,and the lim-its of quantitation were 0.050 0-5.00 ng/L.At different spiked levels,the average recoveries in drinking water were 83.2％-117％,with relative standard deviations(RSDs)ranging from 3.9％to 13％,and the average recoveries in surface water were 92.4％-111％,with RSDs ranging from 3.5％to 14％.The method was successfully applied to the quantitative analysis of 11 neonicotinoid pesti-cides in drinking water and surface water samples collected from Chengdu.Thiamethoxam,imidaclo-prid,clothianidin,acetamiprid,and dinotefuran were detected at varying levels,with concentra-tions ranging from 1.18 to 148 ng/L.