真菌中选择性自噬受体Nbr1的研究进展OA

[Background]Autophagy is a highly conserved intracellular degradation and recycling pathway in eukaryotes,among which selective autophagy maintains cellular homeostasis by specifically recognizing substrates via selective autophagy receptor(SAR).Neighbor of BRCA1 gene 1(Nbr1),a typical SAR widely distributed across eukaryotes,exhibits unique structural and functional characteristics compared with the well-studied p62/SQSTM1.In fungi,Nbr1 and its homologs are involved in multiple key biological processes,including pexophagy,vacuolar targeting of cytoplasmic hydrolases,regulation of growth and development,stress responses and virulence control of pathogenic fungi.[Progress]This review summarizes current research progress on fungal Nbr1,focusing on its conserved structural features(ZZ domain,FW domain,LIR/AIM motif,etc),the selective autophagy pathways it mediates(pexophagy and Nbr1-mediated vacuolar targeting pathway),its biological functions and evolutionary dynamics in fungi.[Prospect]Multiple knowledge gaps persist in research on fungal Nbr1.Combined with the adoption of cutting-edge technol-ogies and continuous in-depth exploration,future studies will likely unravel its intricate functions and regulatory mechanisms,there-by enriching the theoretical framework governing selective autophagy in fungi.