植物病原真菌逆转运复合体的研究进展OA

[Background]The survival and colonization of plant pathogenic fungi depend on the homeostatic regulation of their intra-cellular membrane systems.Vesicle transports,the key hub for regulation of intracellular endocytosis,secretion and circulation,play crucial roles in cellular material exchange and information communication.Among them,retrograde transport is particularly critical in maintaining the protein homeostasis of intracellular membrane system.[Progress]This review focuses on the retromer complex,a core regulatory element governing vesicle retrograde transport.We systematically introduce distinct assemblies formed by cargo-selec-tive complexes with various sorting nexins and phosphoinositide-binding WD40 repeat proteins,as well as their functions in media-ting membrane trafficking and membrane scission.Furthermore,we elaborate the upstream and downstream molecular pathways through which the canonical retromer complex regulates critical biological processes including growth,development and pathogenicity in plant pathogenic fungi.At present,additional subunits and biological functions of the retromer complex in plant pathogenic fungi remain poorly characterized,and a comprehensive understanding of the regulatory mechanisms underlying vesicle retrograde transport is still lacking.[Prospect]With the development and application of cutting-edge technologies such as artificial intelligence and cryo-electron microscopy,further dissection on the molecular mechanisms by which distinct retromer assemblies mediate the pathogenicity of plant pathogenic fungi will provide a theoretical foundation for developing novel molecular agents specifically targeting vesicle ret-rograde transport.