植物细胞膜定位的免疫共受体的研究进展OA

[Background]Plant plasma membrane-localized immune coreceptors are core components of the plant innate immune sys-tem,and play pivotal roles in initiating immune responses.[Progress]Immune coreceptors form functional complexes with corre-sponding receptors at the cell membrane.Through these complexes,the plants can recognize signal molecules derived from pathogen-ic microorganisms or plants themselves,activate immune responses,and achieve broad-spectrum and durable disease resistance in plants.Notably,immune coreceptors play critical roles throughout receptor-ligand recognition,receptor complex activation and im-mune signal transduction processes.This paper mainly reviews the research advances of plant plasma membrane immune coreceptors,elaborates the identification,biological functions and regulatory mechanisms of typical plasma membrane immune coreceptors inclu-ding BRI1-ASSOCIATED RECEPTOR KINASE 1(BAK1),CHITIN ELICITOR RECEPTOR KINASE 1(CERK1)and SUPPRES-SOR OF BAK1-INTERACTING RECEPTOR-LIKE KINASE 1-1(SOBIR1).[Prospect]Future work will focus on identifying novel immune co-receptors and elucidating the molecular mechanisms underlying their regulatory pathways.The artifical intelligence and gene editing are integrated to redesign these receptors for improved functionality,ultimately advancing their translational application in crop disease resistance breeding and enabling precision enhancement of plant immunity.