纳米孔单分子传感信号的识别方法研究OA

As a novel single-molecule technology,nanopore sensing has been widely used in gene sequencing,protein identification and virus screening.In contrast to the wide application fields of nanopore sensing,the accurate identification and high-throughput processing of nanopore signals remain a fundamental technical challenge due to the massive signals of high bandwidth and the inevitable strong noise background.Therefore,the typical methods of nanopore signal processing in recent years are systematically reviewed,and algorithms and performances are analyzed,in order to better require the single molecule information of nanopore sensing signals statistically.The results will promote the development and application of nanopore sensors in different fields including informational omics,biomedical diagnosis and treatment,and health safety.