养心安神方治疗气阴两虚型老年射血分数保留型心力衰竭患者的临床疗效OA
The Clinical Efficacy of Yangxin Anshen Formula in the Treatment of Elderly Patients with Heart Failure with Preserved Ejection Fraction of Qi-Yin Deficiency Pattern
目的 观察养心安神方联合常规西药治疗气阴两虚型老年射血分数保留型心力衰竭(HFpEF)的临床疗效及安全性.方法 选取符合纳入标准的气阴两虚型老年HFpEF患者98例,依据随机数字表随机分为对照组和治疗组,脱落后最终纳入完成病例90例,每组各45例.对照组给予西医常规治疗,包括ACEI/ARB、β受体阻滞剂、利尿剂等;治疗组在对照组基础上口服养心安神方,两组均治疗4周.比较两组患者治疗前后B型利钠肽(BNP)、六分钟步行试验(6MWT)、可溶性生长刺激表达基因2(sST2)、生长分化因子-15(GDF-15)、明尼苏达生活质量评分及安全性指标(肝肾功能、电解质)的变化,并比较纽约心脏病学会(NYHA)心功能分级疗效和中医证候疗效.结果 治疗后,治疗组BNP、sST2、GDF-15水平及明尼苏达生活质量评分均显著低于对照组(BNP:P=0.036;sST2、GDF-15、明尼苏达生活质量评分:P<0.001),6MWT显著高于对照组(P<0.05).治疗组心功能分级总有效率为88.9%(40/45),对照组为71.1%(32/45),组间比较显示治疗组疗效更优(P=0.019).治疗组中医证候总有效率为95.6%(43/45),高于对照组的66.7%(30/45)(P<0.05).两组治疗前后安全性指标均正常,差异无统计学意义(P>0.05).结论 养心安神方联合西医常规疗法治疗气阴两虚型老年HFpEF患者,可有效降低BNP、sST2、GDF-15等心功能相关生物标志物水平,显著改善患者运动耐量、心功能分级及中医临床症状,提升生活质量,且具有良好的安全性.
Objective To explore clinical efficacy and safety of Yangxin Anshen Formula combined with conventional Western medicine in the treatment of elderly patients with heart failure with preserved ejection fraction(HFpEF)of qi-yin deficiency pattern.Methods A total of 98 elderly patients with HFpEF of qi-yin deficiency pattern who met the inclusion criteria were randomly divided into a control group and a treatment group using a random number table.After dropouts,90 patients completed the study,with 45 cases in each group.The control group received conventional Western medicine treatment(including ACEI/ARB,β-blockers,and diuretics),while the treatment group received Yangxin Anshen Formula orally on the basis of the control group.Both groups were treated for 4 weeks.The two groups were compared in terms of changes in B-type natriuretic peptide(BNP),6-min walk test(6MWT),soluble suppression of tumorigenicity 2(sST2),growth differentiation factor 15(GDF-15),and Minnesota Living with Heart Failure Questionnaire(MLHFQ)scores and safety parameters(liver and renal function,electrolytes),as well as the New York Heart Association(NYHA)cardiac function classification efficacy,and traditional Chinese medicine(TCM)symptom score efficacy before and after treatment.Results After the treatment,the levels of BNP,sST2,GDF-15,and MLHFQ scores in treatment group were significantly lower than control group(BNP:P=0.036;sST2,GDF-15,and MLHFQ scores:P<0.001),while the 6MWT distance was significantly higher in the treatment group than in the control group(P<0.05).The total effective rate of cardiac function improvement was 88.9%(40/45)in the treatment group and 71.1%(32/45)in the control group,and the comparison between groups showed that the treatment group had superior efficacy(P=0.019).The total effective rate of TCM symptom score was 95.6%(43/45)in the treatment group,which was significantly higher than 66.7%(30/45)in control group(P<0.05).Safety indicators remained normal in two groups,with no statistically significant differences between two groups(P>0.05).Conclusion Yangxin Anshen Formula combined with conventional Western medicine in the treatment of elderly patients with HFpEF of qi-yin deficiency pattern can effectively reduce the levels of cardiac function-related biomarkers such as BNP,sST2,and GDF-15,significantly improve their exercise tolerance,cardiac function classification,and TCM clinical symptoms,enhance quality of life,and exhibits good safety.
方卉;钱丽超;武立华;翟志慧;王曾晶;贾海波;骆天炯
南京中医药大学附属南京中医院,江苏 南京 210022南京中医药大学附属南京中医院,江苏 南京 210022南京中医药大学附属医院,江苏 南京 210029南京中医药大学附属南京中医院,江苏 南京 210022南京中医药大学附属南京中医院,江苏 南京 210022南京市第一医院,江苏 南京 210006南京中医药大学附属南京中医院,江苏 南京 210022
射血分数保留型心力衰竭气阴两虚型养心安神方临床疗效
Preserved ejection fraction heart failureQi-yin deficiency patternYangxin Anshen FormulaClinical efficacy
《中医药信息》 2026 (9)
58-63,6
江苏省中医药学会青年科技人才托举工程项目(苏中会[2025]59号)
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